Lead Researcher, Protein Kinase Technologies Center

St. Jude Children's Research Hospital

Lauderdale Courts (TN)

On-site

USD 60,000 - 105,000

Full time

2 days ago

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Job summary

St. Jude Children's Research Hospital in Memphis, TN seeks a Lead Researcher to advance our Protein Technologies Center/Blue Sky Kinases project, exploring the human kinome with biophysical and structural approaches.

The role emphasizes cloning, purification, and integrative structural biology work to uncover kinase regulation and disease mechanisms. The candidate will collaborate across disciplines, prepare proteins from various expression systems, and contribute to high-quality structural

Qualifications

Bachelor's degree in a relevant scientific area required.
5+ years of research experience with a Bachelor's; 3+ with a Master's; no PhD required.
Strong knowledge of molecular biology and structural biology principles.

Responsibilities

Independently perform and lead molecular cloning and protein purification experiments.
Biophysically characterize the proteins and perform various biochemical assays.
Screen protein crystals for X-ray crystallography and freeze grids for Cryo-EM.
Handle insect and mammalian cell cultures for protein production.
Experience with at least one structural biology technique, such as cryo-EM or X-ray crystallography, and the ability to refine, model-build, and interpret protein structures.
Analyze and interpret experimental data and prioritize experiments for structural studies.
Maintain comprehensive and well-organized experimental records.