Senior Scientist – Immunology and biotherapeutics

U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc.; Cambridge (MA); In loco; USD 99.000 - 183.000; Tempo pieno

Vantaggi offerti da questo lavoro

Health benefits

Life insurance

Disability benefits

401(k) with match

Generous paid time off

Descrizione del lavoro

Novartis Institutes for BioMedical Research, Inc. in Cambridge, MA, is seeking a senior scientist to lead immunology-focused studies and immune profiling for novel biotherapeutics, including AOC/xRNA modalities.

The role involves designing assays with primary cells, coordinating with immunology and translational teams, and communicating results to project teams in a fast-paced Biologics Research Center environment.

Competenze

• Recent Ph.D. graduate (0-1 year) or MSc in Life Science, preferably immunology or cell biology with 2–5 years of research experience in human immunology or cell biology in industry or academic settings.
• Deep expertise in human immunology and immune assay development, preferably using primary immune cells, multicellular assay systems, tissue-relevant models, or disease-relevant ex vivo platforms.
• Experience assessing immunogenicity, immune activation, cytokine release, anti-drug immune responses, or immune-related liabilities for biologics or emerging therapeutic modalities.
• Demonstrated ability to critically analyze data, learn and combine new techniques quickly, design and prioritize experiments.
• Proficiency with immunological and molecular readouts such as flow cytometry, immunoassays, qPCR, transcriptomics or imaging.
• Scientific curiosity, initiative, commitment, flexibility and good organization and presentation skills.
• Work independently and as a team member with open communication with groups and collaborators.

Mansioni

• Design, establish, and execute immunology-focused profiling strategies to evaluate immune cell activation, modulation, cytokine release, innate immune sensing, adaptive immune responses, and disease-relevant functional outcomes.
• Collaborate closely with teams in immunology, disease biology, oligonucleotide biology, antibody engineering, bioanalytics, toxicology, and translational medicine to align assay strategy with program needs.
• Regularly communicate and present results, prepare reports, representing the Unit in project teams.

Conoscenze

Immunology

Flow cytometry

Immune profiling

qPCR

Data analysis

Independent work

Team collaboration

Formazione

Recent PhD or MSc in Life Science

Descrizione del lavoro

Band Level 3 Job Description Summary WORK ARRANGEMENT: On-Site Working, #On-site LOCATION: Cambridge, MA RELOCATION SUPPORT: This role is based in Cambridge, United States. Novartis is unable to offer relocation support: please only apply if accessible. We are seeking a highly motivated senior scientist with strong expertise in human immunology, immune profiling, and disease-relevant multicellular assay systems, combined with working knowledge of xRNA biotherapeutics and general immunogenicity principles. The successful candidate will lead immunology-focused studies to evaluate how novel biotherapeutic modalities, including antibody-oligonucleotide conjugates (AOCs) and related xRNA approaches, interact with immune cells and pathways.

The Immunogenicity and Mechanistic Immunology unit in the Biologics Research Center (BRC) focuses on immune profiling and immunogenicity assessment that inform the characterization and optimization of biotherapeutics, including antibody-oligonucleotide conjugates (AOC) expansion across disease areas. The scientist will join our Cambridge immunology team and work in matrix multidisciplinary project teams to design and execute immune profiling studies tailored to specific target tissues and disease to support the selection of safe and effective AOC in various disease areas.

KEY RESPONSIBILITIES

• Design, establish, and execute immunology-focused profiling strategies to evaluate immune cell activation, modulation, cytokine release, innate immune sensing, adaptive immune responses, and disease-relevant functional outcomes. Competent and independent in executing and analyzing complex assays involving primary cells (including primary immune and non-immune cells), multicolor FACS analysis and functional immunological assays Generates hypotheses, designs and executes experiments, critically analyzes and interprets data, able to prioritize experiments and design follow-up experiments Generate mechanistic immunology data packages to support candidate optimization, translational biomarker hypotheses, safety risk assessment, and decision-making across discovery and early development programs. Collaborate closely with teams in immunology, disease biology, oligonucleotide biology, antibody engineering, bioanalytics, toxicology, and translational medicine to align assay strategy with program needs. Regularly communicate and present results, prepare reports, representing the Unit in project teams Open mindset, organization skills and ability and eagerness to develop novel assays or analysis tools based on project needs in different disease areas Maintain familiarity with scientific and technical literature pertinent to the projects Video Link https://www.youtube.com/watch?v=aJbkTX4VueQ

ESSENTIAL REQUIREMENTS

• Recent Ph.D. graduate (0-1 year) or MSc in Life Science, preferably immunology or cell biology plus 2–5-year research experience in human immunology or cell biology in industry or academic settings
• Deep expertise in human immunology and immune assay development, preferably using primary immune cells, multicellular assay systems, tissue-relevant models, or disease-relevant ex vivo platforms.
• Experience assessing immunogenicity, immune activation, cytokine release, anti-drug immune responses, or immune-related liabilities for biologics or emerging therapeutic modalities.
• Demonstrated ability to critically analyze data, learn and combine new techniques and concepts quickly, design and prioritize experiments.
• Proficiency with immunological and molecular readouts such as flow cytometry, immunoassays, qPCR, transcriptomics or imaging.
• Scientific curiosity, initiative, commitment, flexibility and good organization and presentation skills.
• Work independently and as a team member with open communication with groups and collaborators.

DESIRABLE REQUIREMENTS

• Working knowledge of xRNA biotherapeutics, AOC or antibody-based delivery platforms is highly desirable.
• Experience in orthogonal omics data analysis is a plus but not mandatory.

Why Novartis?

Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. With our people, we are committed to achieving this mission. Be a part of this mission and join us.

REWARDS

The salary for this position is expected to range between $98,700 & $183,300 per year. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors. Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards. US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.

• performance-based cash incentive
• eligibility to be considered for annual equity awards
• health, life and disability benefits
• 401(k) with company contribution and match
• variety of other benefits
• generous time off package including vacation, personal days, holidays and other leaves

Salary Range $98,700.00 - $183,300.00

EEO Statement

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Accessibility and reasonable accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to [e-mail] call [phone] and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

SKILLS DESIRED

• Analytical Thinking
• Chemical Biology
• Chemistry
• Clinical Research
• Clinical Trials
• Collaboration
• Curious Mindset
• Data Analysis
• Detail-Oriented
• Ethics
• Gene Therapy
• Immunology
• Machine Learning (ML)
• Mammalian Cell Culture
• Medical Research
• Molecular Biology
• Patient Care
• Science