Senior IHC Scientist – Multiplex & Imaging Expert

SmartRecruiters, Inc.; Worcester (MA); On-site; USD 100,000 - 180,000; Full time

Job summary

AbbVie is seeking an experienced immunohistochemistry scientist to advance drug discovery programs within a collaborative Pathology team. You will design and optimize single-plex and multiplex IHC/IF assays, working with pathologists, project teams, and histotechnologists to generate quantitative data and robust assays.

The role emphasizes assay development, technical leadership, and mentoring while maintaining compliant records in a fast-paced environment in Worcester, MA.

Qualifications

• Bachelor’s degree in biology/chemistry or related field with 10 years of experience or master’s degree with 8 years of experience
• Bachelor’s or master’s degree in biology, pathology, life sciences, or a related discipline, with relevant industry experience
• Demonstrated experience performing immunohistochemistry and immunofluorescence assays
• Thorough knowledge of the Opal mIF platform, including assay development, optimization, and troubleshooting
• Experience with image analysis and the ability to understand how image-analysis methods affect assay quality and quantitative endpoints
• Ability to work independently, prioritize workload, and manage multiple projects and deadlines
• Strong attention to detail and commitment to generating accurate, reproducible, and well-documented results
• Excellent communication and collaboration skills, including the ability to present technical findings clearly to cross-functional project teams
• Microsoft office skills

Responsibilities

• Independently design and execute single-plex and multiplex immunohistochemistry and immunofluorescence assays ensure assay execution meets established quality and performance criteria
• Partner with pathologists and project teams to determine the most appropriate assay design and experimental approach for key project questions, including questions related to target validation and expression aligned with project objectives and timelines
• Develop, optimize, and troubleshoot assays using the Opal and Leica Bond Rx platforms with minimal input from pathologists
• Analyze results and present clear, well-organized findings with representative images and quantitative data
• Provide technical leadership in IHC panel design, assay optimization, and complex assay development
• Apply a thorough understanding of image analysis to support the complete assay-development process, from assay design through endpoint generation
• Mentor junior scientists and promote consistent, high-quality laboratory practices
• Evaluate emerging technologies and communicate relevant opportunities to the team
• Use Sample Manager, DreamPath, and other laboratory systems to document and track activities
• Maintain accurate, timely, and compliant experimental records

Skills

Immunohistochemistry

Immunofluorescence

Image analysis

Project prioritization

Mentoring

Communication

Education

Bachelor's or Master in biology/chemistry or related field

Relevant industry experience

Tools

Opal mIF

Leica Bond Rx

Sample Manager

DreamPath

Job description

AbbVie is seeking an experienced immunohistochemistry scientist to advance drug discovery programs within a collaborative Pathology team. You will design and optimize single-plex and multiplex IHC/IF assays, working with pathologists, project teams, and histotechnologists to generate quantitative data and robust assays.

The role emphasizes assay development, technical leadership, and mentoring while maintaining compliant records in a fast-paced environment in Worcester, MA.