Scientist R&D – Immunohistochemistry (IHC) & Histology

Natera; United States; On-site; USD 125,000 - 140,000; Full time

Job summary

Scorpion Therapeutics seeks an R&D Scientist with expertise in Immunohistochemistry (IHC) and Histology within Oncology Product Development to advance tissue-based workflows for oncology assays. You will design studies, optimize staining, troubleshoot Roche BenchMark ULTRA, and drive method transfer into clinical lab workflows.

The role emphasizes cross-functional collaboration and thorough documentation of protocols, validation reports, and SOPs.

Qualifications

• PhD in Pathology, Cancer Biology, or related field with ≥2 years industry experience.
• Alternative: Master’s with ≥5 years or Bachelor’s with 6–8+ years relevant experience.
• Experience in IHC assay development and FFPE tissue workflows.

Responsibilities

• Design and execute studies for IHC and tissue workflows.
• Optimize assay parameters including antibody selection, antigen retrieval, and staining conditions.
• Troubleshoot automated staining platforms (notably Roche BenchMark ULTRA).
• Evaluate pre-analytical tissue variables.
• Collaborate with cross-functional teams to transfer methods into clinical laboratory workflows.
• Develop documentation such as protocols, validation reports, SOPs, and provide technical guidance.

Skills

IHC assay development

Histology

FFPE workflows

Automated platforms

Education

PhD in Pathology or Cancer Biology

Master's with ≥5 years experience

Bachelor's with 6–8+ years experience

Tools

Roche BenchMark ULTRA

Job description

Role

R&D Scientist specializing in Immunohistochemistry (IHC) and Histology within Oncology Product Development, focusing on developing, optimizing, verifying, and validating tissue-based workflows for oncology assays.

Responsibilities

• design and execute studies for IHC and tissue workflows,
• optimize assay parameters including antibody selection, antigen retrieval, and staining conditions,
• troubleshoot automated staining platforms (notably Roche BenchMark ULTRA),
• evaluate pre-analytical tissue variables,
• collaborate with cross-functional teams to transfer methods into clinical laboratory workflows.
• develop documentation such as protocols, validation reports, SOPs, and provide technical guidance.

Requirements

• Ph.D. in Pathology, Cancer Biology, or related field with ≥2 years industry experience, or Master's with ≥5 years, or Bachelor's with 6–8+ years relevant experience.

Essential skills

• hands-on expertise in IHC assay development, histology, FFPE tissue workflows, and experience with automated platforms.

Preferred

• experience with NGS, molecular biology workflows, digital pathology, and in regulated clinical or molecular diagnostics environments.

High-Value

• Oncology focus, tissue-based assays, regulated lab setting, and automation platforms.

Work setup

Remote USA, with a salary range of $125,000–$140,000.