Senior GPCR Pharmacology Scientist Lead Candidate Characterization

Genentech, Inc.; South San Francisco (CA); On-site; USD 143,000 - 266,000; Full time

Benefits offered by this job

Relocation assistance

Benefits package

Job summary

Genentech, Inc. in South San Francisco seeks a Senior Scientist to lead GPCR pharmacology initiatives. You will develop and apply advanced molecular pharmacology assays, interpret complex data, and guide project teams toward IND-ready candidates.

PhD with 4–12 years of experience required; strong leadership, collaboration, and communication skills are essential. Onsite role with relocation assistance and a competitive salary structure.

Qualifications

• Ph.D. in Pharmacology, Biochemistry, Cell Biology, or related field with 4–12 years postdoc/industry experience.
• Deep expertise in GPCR pharmacology, receptor theory, signal transduction, allosteric modulation, and biased signaling.
• Experience across GPCR assay platforms (cAMP, calcium flux, BRET/FRET, Beta-arrestin).
• Experience with primary cells and gene editing (CRISPR).
• Strong leadership and ability to mentor scientists and work in cross-functional teams.

Responsibilities

• Provide strategic leadership as GPCR expert on multidisciplinary teams.
• Oversee in vitro pharmacological characterization to advance lead candidates.
• Design and optimize complex molecular pharmacology assays in transfected and primary cells.
• Collaborate and mentor Scientist partners to execute experiments and analyze data.
• Present findings to stakeholders and leadership.
• Evaluate new technologies to enhance pharmacological capabilities.

Skills

GPCR pharmacology

In vitro pharmacology

Molecular pharmacology assays

Leadership & mentoring

Data analysis & presentation

Education

Ph.D. in Pharmacology or related field

Tools

cAMP

Calcium flux

BRET/FRET

Beta-arrestin recruitment

Primary cell work & CRISPR

Job description

Genentech, Inc. in South San Francisco seeks a Senior Scientist to lead GPCR pharmacology initiatives. You will develop and apply advanced molecular pharmacology assays, interpret complex data, and guide project teams toward IND-ready candidates.

PhD with 4–12 years of experience required; strong leadership, collaboration, and communication skills are essential. Onsite role with relocation assistance and a competitive salary structure.