Senior Scientist- Translational PKPD

Roche; South San Francisco (CA); On-site; USD 121,000 - 224,000; Full time

Job summary

Genentech is seeking a Senior Scientist to support translational PKPD efforts, guiding preclinical design and data interpretation for biologics in development. You will lead in vitro and in vivo ADME/PKPD studies, compile summaries, and present findings to teams.

The role requires a PhD/MD/PharmD plus 1–2 years translational experience, with strong analytical skills and GLP familiarity. Collaboration across departments and potential publications are key aspects.

Qualifications

• Ph.D., M.D., or PharmD in pharmacology, pharmaceutical science, biology, or related field required
• 1-2 years industry PKPD/translational experience preferred
• Strong GLP and laboratory safety familiarity; able to work independently or with supervision

Responsibilities

• Design, conduct, analyze, and interpret in vitro/in vivo ADME and PKPD studies in animals to predict human behavior
• Prepare summary tables/reports for non-clinical studies and regulatory documents (INDs/BLAs) under supervision
• Present data at project teams and department meetings; contribute to publications in peer-reviewed journals
• Collaborate with Clinical Pharmacology, Bioanalytical Sciences, Regulatory Affairs, and other functions to advance development programs
• Maintain an active PKPD laboratory program supporting research and pipeline projects

Skills

PKPD knowledge

Critical thinking

Data analysis

Scientific communication

Regulatory awareness

Education

Ph.D./M.D./PharmD or equivalent

Postdoctoral experience (preferred)

Tools

WinNonlin

NONMEM

ADAPT II

Matlab

SimBiology

R

Job description

Why Genentech

We advance science so that we all have more time with the people we love.

This opening is for a Senior Scientist position in the translational Pharmacokinetics and Pharmacodynamics (tPKPD) department within the Development Sciences division in Genentech Research and Early Development (gRED) unit.

The focus of this position is to support the preclinical pharmacokinetic and pharmacodynamics (PKPD) efforts to guide the design, delivery and development of biologics in the Genentech pipeline. Core responsibilities include providing technical support for the PKPD assessment of drug candidates and marketed products and working independently or under the direct supervision of a Scientist.

The Opportunity:

The responsibilities of this Senior Scientist position will :

• Design, conduct, analyze and interpret all in vitro and in vivo ADME and PKPD studies that are necessary to understand the pharmacology of drug candidates in animals and predict their behavior in humans
• Prepare summary tables and reports for non-clinical studies; may prepare documents for regulatory agencies, including INDs and BLAs under the supervision of a Scientist
• Present data at project teams and department meetings and conferences as appropriate
• Publish innovative PKPD focused research in high quality scientific, technical or medical journals.
• Manage an active laboratory program that supports basic research in PKPD and also supports pipeline projects
• Collaborate with other departments such as Clinical Pharmacology, Research, Bioanalytical Sciences, Safety Assessment, PD Biomarker/OMNI, Antibody Engineering, Non-clinical Biostatistics, Regulatory Affairs, Technical Development, and others
• Participate in compliance and safety related activities. Perform other duties, as assigned

Who You Are:

• Ph.D., or M.D., or PharmD degree or equivalent curriculum in pharmacology, pharmaceutical science, biology, bioengineering, chemistry, physiology or related disciplines is required (experience is specific to job level). Persons without a formal degree who have comparable depth and breadth of training and experience (gained at Genentech or elsewhere), and who meet job-specific criteria, are eligible for consideration
• 1-2 years of relevant industry experience in translational PKPD/pharmacology or equivalent Postdoctoral experience is preferred
• Outstanding record of accomplishment in his/her field as evidenced by his/her co authored publications, patents, internal reports and/or regulatory filings.
• Strong knowledge of laboratory techniques and safety is required; Regular GLP and laboratory safety training is required
• Experience in quantitative PKPD software (e.g., WinNonlin, NONMEM, ADAPT II, Matlab, Simbiology, R)
• Demonstrated independent thought and creativity in relevant discipline; independently designs, carries out, analyzes, interprets, and documents studies and experiments.
• Good communication skills, independently presents at department and project teammeeting

The expected salary range for this position based on the primary location of San Franscico, CA is $ 120,700 – $224,100Annual. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.

This position also qualifies for the benefits detailed here:

Benefits

Relocation benefits are not available for this posting.

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company’s policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.