GPCR Pharmacology Lead, Biochemical & Cellular

1000 Genentech, Inc.; South San Francisco (CA); On-site; USD 143,000 - 266,000; Full time

Benefits offered by this job

Relocation assistance

Discretionary annual bonus

Genentech benefits

Job summary

Genentech in South San Francisco, CA, seeks a Senior Scientist to join the Biochemical and Cellular Pharmacology Department. You will apply GPCR pharmacology to establish screening cascades and guide IND candidate selection, contributing across bench and leadership levels.

You will develop and optimize sophisticated molecular pharmacology assays, mentor scientists, and communicate high-impact findings to project teams and executives.

Qualifications

• Ph.D. in Pharmacology, Biochemistry, Cell Biology, or related field with 4–12 years of postdoctoral and/or industry experience.
• Hands-on experience across diverse GPCR assay platforms (e.g., cAMP, calcium flux, BRET/FRET, Beta-arrestin recruitment).
• Expertise in cardiovascular, renal, or metabolic disease fields.
• Experience with primary cells and gene-editing techniques (e.g., CRISPR).
• Proven track record in developing, optimizing, and troubleshooting biochemical and cell-based assay cascades.

Responsibilities

• Serve as the primary GPCR expert on multidisciplinary project teams and contribute at leadership levels.
• Oversee in vitro pharmacological characterization to advance lead candidates in relevant disease areas.
• Lead development, optimization, and execution of complex molecular pharmacology assays (protein interactions, second messengers, biosensors).
• Mentor and collaborate with Scientist partners to design experiments and ensure robust data analysis.
• Communicate findings and strategic directions to stakeholders and senior leadership.

Skills

GPCR pharmacology

In vitro pharmacology

Signal transduction

Protein–protein interactions

Biased signaling

CRISPR gene editing

Education

PhD in Pharmacology or related field

Tools

cAMP assay

Calcium flux

BRET/FRET

β-arrestin recruitment

Job description

Genentech in South San Francisco, CA, seeks a Senior Scientist to join the Biochemical and Cellular Pharmacology Department. You will apply GPCR pharmacology to establish screening cascades and guide IND candidate selection, contributing across bench and leadership levels.

You will develop and optimize sophisticated molecular pharmacology assays, mentor scientists, and communicate high-impact findings to project teams and executives.