Senior Scientist, Biochemical & Cellular Pharmacology

Genentech; South San Francisco (CA); On-site; USD 103,000 - 192,000; Full time

Benefits offered by this job

Relocation assistance

Benefits package

Job summary

Genentech, located in South San Francisco, CA, seeks a seasoned scientist to advance cardio-metabolic drug discovery. You will design and execute complex biochemical and cell-based assays in relevant systems, support lead finding through optimization, and define target candidate profiles.

The role emphasizes independent work, collaboration, and cutting-edge technology in a fast-paced environment. You will lead mechanistic studies, drive screening cascades, and accelerate timelines with automated

Qualifications

• Bachelor’s degree in Cell Biology, Pharmacology, Biochemistry, or related field.
• 8+ years of hands-on research experience in pharma/biotech environments.
• Expert-level proficiency in culturing and performing assays on mammalian and primary cells, including cardiomyocytes.
• Knowledge of GPCR signaling pathways and pharmacological characterization.
• Hands-on experience with microplate biochemical and cellular assays (HTRF, AlphaScreen, luminescence).
• Strong problem-solving, independence, and teamwork abilities.
• Organized, detail-oriented, with excellent time management and communication skills.

Responsibilities

• Design and execute rigorous experiments independently; troubleshoot issues and analyze complex data.
• Drive screening efforts across multiple projects with functional assays and technologies.
• Pioneer novel assay platforms to interrogate receptor pharmacology and mechanism of action; review literature to guide initiatives.
• Drive automation and efficiency using laboratory robotics to streamline workflows.
• Collaborate across multidisciplinary teams; generate high-quality presentations and communicate findings to stakeholders.

Skills

Mammalian cell culture

GPCR signaling

Biochemical assays

High-content screening

Team collaboration

Data analysis

Education

Bachelor’s or higher in Cell Biology/Pharmacology/Biochemistry

Tools

CRISPR

Flow cytometry

HTRF/AlphaLISA

Lab automation (Bravo/Tecan/Echo)

Job description

Genentech, located in South San Francisco, CA, seeks a seasoned scientist to advance cardio-metabolic drug discovery. You will design and execute complex biochemical and cell-based assays in relevant systems, support lead finding through optimization, and define target candidate profiles.

The role emphasizes independent work, collaboration, and cutting-edge technology in a fast-paced environment. You will lead mechanistic studies, drive screening cascades, and accelerate timelines with automated