Senior GPCR Pharmacology Scientist

Genentech; San Francisco (CA); On-site; USD 143,000 - 266,000; Full time

Benefits offered by this job

Relocation assistance

Job summary

Genentech, Inc. seeks a Senior Scientist to drive GPCR pharmacology efforts within Biochemical and Cellular Pharmacology. You will shape program directions, develop advanced assays, and mentor junior scientists across multidisciplinary teams in a fast-paced environment.

Located onsite in South San Francisco, CA, this role emphasizes collaboration, data analysis, and strategic leadership to advance therapeutic candidates, with relocation support and a discretionary annual bonus opportunity.

Qualifications

• Ph.D. in Pharmacology, Biochemistry, Cell Biology, or a related scientific discipline.
• 4–12 years of postdoctoral and/or industry experience.
• Hands-on experience with GPCR assays and mechanistic pharmacology.

Responsibilities

• Lead development and execution of GPCR assay cascades and pharmacology characterization.
• Mentor scientists, collaborate across Biology, Medicinal Chemistry, and Protein Sciences.
• Communicate data-driven findings to project teams and leadership.

Skills

GPCR pharmacology

receptor theory

signal transduction

allosteric modulation

biased signaling

cAMP assays

calcium flux

BRET/FRET

Beta-arrestin

data analysis

Education

Ph.D. in Pharmacology, Biochemistry, Cell Biology, or related

Tools

CRISPR

Computational tools

Job description

Genentech, Inc. seeks a Senior Scientist to drive GPCR pharmacology efforts within Biochemical and Cellular Pharmacology. You will shape program directions, develop advanced assays, and mentor junior scientists across multidisciplinary teams in a fast-paced environment.

Located onsite in South San Francisco, CA, this role emphasizes collaboration, data analysis, and strategic leadership to advance therapeutic candidates, with relocation support and a discretionary annual bonus opportunity.