Scientist 3, Biochemical and Cellular Pharmacology

Genentech; San Francisco (CA); On-site; USD 103,000 - 192,000; Full time

Benefits offered by this job

Relocation assistance

Job summary

Genentech, in South San Francisco, CA, seeks an experienced scientist to drive discovery and characterization of cardiometabolic drug candidates. You will develop biochemical and cell-based assays in relevant systems to evaluate therapeutic candidates across cardio-metabolic areas.

You will design independent experiments, support project lead finding through optimization, and contribute to mechanistic studies of receptor signaling and protein interactions to shape candidate profiles.

Qualifications

• 8+ years of hands-on pharma/biotech research.
• Expert in mammalian cell culture and assays including cardiomyocytes.
• Experience with GPCR signaling and pharmacology characterization.
• CRISPR gene-editing and stable cell line generation experience.
• Strong problem-solving and collaboration skills.

Responsibilities

• Design and execute experiments independently; troubleshoot and analyze complex data.
• Drive screening efforts across projects using functional assays and technologies.
• Develop and validate novel assay platforms for receptor pharmacology and mechanism of action.
• Advance automation using robotics (Bravo, Tecan, Echo) to accelerate timelines.
• Collaborate across cross-functional teams and present findings to stakeholders.

Skills

Cell biology

Pharmacology

Biochemistry

Mammalian cell culture

CRISPR gene editing

GPCR signaling

Data analysis

High-throughput screening

Education

BS/MS in Cell Biology/Pharmacology/Biochemistry

Tools

GraphPad Prism

Genedata

Excel

Python

R

Job description

The Position

Join Genentech's Biochemical and Cellular Pharmacology Department and help shape the future of cardio-metabolic therapeutics. We are seeking a creative, motivated scientist to drive the discovery and characterization of innovative drug candidates that could transform patient outcomes.

Operating at the intersection of cutting-edge science and drug development, you will support the selection and characterization of therapeutic candidates across our pipeline. In this role, you will develop, validate, and execute sophisticated biochemical and cell-based assays in heterologous and physiologically relevant systems to evaluate drugs in cardiovascular, renal and metabolic areas. You will support projects from initial lead finding through optimization, conducting detailed mechanistic studies on complex receptor signaling pathways and protein interactions. Ultimately, your scientific insights will help define target candidate profiles and shape the screening cascades that deliver our next-generation therapeutics.

The Opportunity

• Design and execute rigorous experiments independently, troubleshoot issues, analyze complex data using advanced computational tools and software, and document results
• Drive screening efforts across multiple projects, leveraging a comprehensive toolkit of functional assays and technologies
• Pioneer novel assay platforms that interrogate complex receptor pharmacology and mechanism of action, showing scientific curiosity and reviewing literature to drive your initiatives
• Drive automation and efficiency using laboratory robotics (Bravo, Tecan, Echo…) to streamline workflows and accelerate timelines
• Collaborate across multidisciplinary teams in a fast-paced environment, generate high-quality presentations, and communicate findings to stakeholders

Who You Are

• Bachelor's degree and/or Master's degree in Cell Biology, Pharmacology, Biochemistry, or related field
• 8+ years of hands-on research experience in fast-paced pharma or biotech environments
• Expert-level proficiency in culturing and performing assays on a wide range of mammalian and primary cells (including cardiomyocytes), as well as in stable cell line generation and gene-editing techniques (e.g., CRISPR).
• Knowledgeable in G-protein coupled receptor (GPCR) signaling pathways, ligand-receptor binding kinetics, and standard pharmacological characterization
• Hands-on experience with a variety of microplate-format biochemical and cellular assays (e.g., HTRF, AlphaScreen, or luminescence-based readouts)
• A critical thinker with strong problem-solving abilities and scientific rigor
• Independent and collaborative—equally comfortable leading your own work and working as a team
• Organized and detail-oriented, with excellent time management skills
• An excellent communicator (written and verbal) who can work seamlessly across cross-functional project teams

Preferred Qualifications

• Expertise in the cardiovascular, renal, or metabolic disease field
• Experience with flow cytometry, ELISA assays, or high-content image analysis
• Experience with lab automation and high-throughput screening
• Proficiency with data analysis software and visualization tools (GraphPad Prism, Genedata, Excel, Python, R)

Together, we’ll advance along the whole patient journey with the aspiration to prevent, stop and cure diseases.

This is an onsite position in South San Francisco, CA.

This position is eligible for relocation assistance.

The expected salary range for this position based on the primary location of San Francisco, CA is $103,400.00 - $192,000.00 Annual USD. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.

This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.