Senior Genome Editing Researcher

Colossal Biosciences; Dallas (TX); On-site; USD 85,000 - 120,000; Full time

Benefits offered by this job

Medical, dental, and vision coverage

Paid time off

Flexible spending accounts (FSA)

Company matched 401k retirement plan

Paid parental leave at 100% salary for

Education reimbursement

Relocation assistance

Job summary

Colossal Biosciences is hiring an experienced Research Associate/Senior Research Associate to advance precision genome engineering in non-model mammalian organisms. You will prepare, validate, and transfer CRISPR/Cas9, prime editing, base editing, and multiplex editing reagents to support edited cell line generation.

This on-site Dallas, TX role offers relocation assistance and an opportunity to contribute from day one with established workflows and cross‑functional collaboration.

Qualifications

• BA/BS or MA/MS in molecular biology, genetics, biotechnology, bioengineering or related field.
• Hands-on molecular biology research experience including cloning, PCR, plasmid prep and sequence verification.
• Practical experience supporting CRISPR/Cas9 genome editing and multiplex editing workflows.
• Experience preparing, handling, and quality-controlling DNA and/or RNA editing reagents.
• Ability to independently execute established protocols and troubleshoot with limited training.

Responsibilities

• Generate and quality-control genome editing reagents (sgRNAs, pegRNAs, donor DNA templates, plasmids, expression constructs).
• Perform molecular cloning, DNA assembly, bacterial culture, plasmid purification, PCR, and sequence verification.
• Support RNA reagent preparation and purification (in vitro transcription where applicable).
• Prepare and track reagent sets for multiplex genome editing experiments with accurate records.
• Collaborate with Genome Engineering to implement CRISPR/Cas9, prime editing, and base editing designs.

Skills

Molecular biology

Genetics

Biotech background

Documentation & communication

Education

BA/BS or MA/MS in molecular biology/Genetics/Biotechnology/Bioengineering

Job description

Colossal Biosciences is hiring an experienced Research Associate/Senior Research Associate to advance precision genome engineering in non-model mammalian organisms. You will prepare, validate, and transfer CRISPR/Cas9, prime editing, base editing, and multiplex editing reagents to support edited cell line generation.

This on-site Dallas, TX role offers relocation assistance and an opportunity to contribute from day one with established workflows and cross‑functional collaboration.