Scientist, Genome Engineering

Colossal Biosciences; Dallas (TX); On-site; USD 70,000 - 100,000; Full time

Benefits offered by this job

Medical, dental, and vision coverage

Paid time off

Flexible spending accounts (FSA)

Company matched 401k retirement plan

Paid parental leave

Education reimbursement

Job summary

Colossal Biosciences in Dallas, TX is seeking a talented Scientist passionate about synthetic biology and large-scale genome engineering. This role involves designing innovative DNA assembly and editing techniques, alongside a skilled team focused on conservation technologies.

Qualifications include a PhD or MS in a relevant field or equivalent hands-on experience. Colossal offers competitive benefits, including medical coverage, 401k matching, and paid parental leave.

Qualifications

• PhD or MS in synthetic biology, bioengineering, molecular biology, or genetics required.
• Experience with DNA/RNA transfection and various genomic editing techniques.
• Strong problem-solving and communication skills.

Responsibilities

• Design and innovate DNA assembly and editing workflows.
• Perform data analysis and maintain a detailed lab notebook.
• Present findings at forums and R&D meetings.

Skills

DNA assembly

Cell culture

Gene editing techniques

Data analysis

Written and oral communication

Education

PhD/MS in synthetic biology or related field

Tools

PCR

Flow cytometry

NGS library prep

Job description

We are looking for a talented Scientist with knowledge and passion for ambitious synthetic biology projects and large-scale genome engineering for species conservation and de‑extinction. We will be building tools and methodologies for engineering various cell types, and will develop workflows to manipulate large DNA fragments and genomes. The candidate will work with a talented group of engineers and biologists committed to developing novel conservation technologies that will change the world.

This position is based in Dallas, TX. Relocation assistance is available.

Duties/Responsibilities

• Design, innovate and iterate: DNA assembly, integration, editing and screening
• Build enabling molecular and cellular tools
• Perform DNA/RNA transfections and/or viral transductions
• Quantify genome editing events using various molecular assays
• Data analysis, figure generation and timely reporting of results
• Present findings at small forums and R&D meetings
• Maintain a thorough and detailed electronic lab notebook
• Maintain a clean and organized laboratory space

Basic Qualifications

• PhD/MS in synthetic biology, bioengineering, molecular biology, genetics or related field is required, or 3+ years hands‑on expertise in genetics and genomic manipulation
• Solid understanding and hands‑on experience with current editing techniques
• Experience with cell culture, DNA/RNA transfection, bacterial culture, recombinant DNA cloning techniques, primer design and PCR, gel electrophoresis, nucleic acid extraction and purification
• Self‑motivated, proactive, works well under pressure and deadlines, detail oriented
• Enthusiasm for learning new skills and taking on new responsibilities
• Strong written and oral communication skills, as well as creative problem‑solving skills
• Enjoys the fast‑paced startup environment and teamwork

Preferred Qualifications

• High throughput screening experience or automation methods
• NGS library prep, immunostaining and flow cytometry experience
• Current experience with next‑generation editing tools

What Colossal Offers Full‑Time Employees

• Medical, dental, and vision coverage
• Excellent paid time off and company holidays so you can rest and recharge
• Flexible spending accounts (FSA)
• Company matched 401k retirement plan
• Paid parental leave at 100% salary for up to 12 weeks
• Education reimbursement
• An opportunity to help us return the Earth to a healthier state

Colossal is proud to be an equal employment opportunity workplace. We welcome people from all backgrounds as well as celebrate and support diversity. We are committed to providing an inclusive environment of mutual respect that is free from discrimination and harassment so everyone can thrive.