Senior Formulations Lead, Small Molecule Drug Product

C4-Therapeutics-Inc; Watertown (MA); On-site; USD 230,000 - 254,000; Full time

Job summary

C4 Therapeutics is seeking a Principal Scientist, Formulations in Watertown, MA to lead the design, early-phase development, and manufacturing scale-up of oral solid dose drug products. You will coordinate with internal teams and external CDMOs to transfer processes into GMP manufacturing for clinical trials.

The role requires a PhD with extensive experience in formulation development, process optimization, and regulatory readiness, ensuring robust, scalable drug products that meet TPPS and

Qualifications

• PhD in Pharmaceutical Chemistry, Formulation Sciences, or related field with 8+ years post-graduate experience in industry.
• Experience leading cross-functional drug product development for solid oral and parenteral dosage forms.
• Familiarity with cGMPs and regulatory guidance during manufacture and testing.

Responsibilities

• Lead phase-appropriate small molecule drug product formulation development for the clinical portfolio.
• Oversee formulation development, process optimization, scale-up, and technology transfer with external CDMOs.
• Direct and evaluate work of external scientists and suppliers, including vendor identification and CDMO selection.
• Provide technical leadership for engineering, clinical, and validation batches and review critical documentation.
• Support CMC strategy and regulatory readiness through authoring memos and specifications.

Skills

Cross-functional leadership

Formulation development

Scale-up

Technology transfer

Education

PhD in pharmaceutical formulation

Job description

C4 Therapeutics is seeking a Principal Scientist, Formulations in Watertown, MA to lead the design, early-phase development, and manufacturing scale-up of oral solid dose drug products. You will coordinate with internal teams and external CDMOs to transfer processes into GMP manufacturing for clinical trials.

The role requires a PhD with extensive experience in formulation development, process optimization, and regulatory readiness, ensuring robust, scalable drug products that meet TPPS and