Principal Scientist, Formulations

C4-Therapeutics-Inc; Watertown (MA); On-site; USD 230,000 - 254,000; Full time

Job summary

C4 Therapeutics is seeking a Principal Scientist, Formulations in Watertown, MA to lead the design, early-phase development, and manufacturing scale-up of oral solid dose drug products. You will coordinate with internal teams and external CDMOs to transfer processes into GMP manufacturing for clinical trials.

The role requires a PhD with extensive experience in formulation development, process optimization, and regulatory readiness, ensuring robust, scalable drug products that meet TPPS and

Qualifications

• PhD in Pharmaceutical Chemistry, Formulation Sciences, or related field with 8+ years post-graduate experience in industry.
• Experience leading cross-functional drug product development for solid oral and parenteral dosage forms.
• Familiarity with cGMPs and regulatory guidance during manufacture and testing.

Responsibilities

• Lead phase-appropriate small molecule drug product formulation development for the clinical portfolio.
• Oversee formulation development, process optimization, scale-up, and technology transfer with external CDMOs.
• Direct and evaluate work of external scientists and suppliers, including vendor identification and CDMO selection.
• Provide technical leadership for engineering, clinical, and validation batches and review critical documentation.
• Support CMC strategy and regulatory readiness through authoring memos and specifications.

Skills

Cross-functional leadership

Formulation development

Scale-up

Technology transfer

Education

PhD in pharmaceutical formulation

Job description

If you are unable to complete this application due to a disability, contact this employer to ask for an accommodation or an alternative application process.

Principal Scientist, Formulations

Full Time Technical Watertown, MA, US

Salary Range: $230,090.00 To $254,310.00 Annually

About C4 Therapeutics:

C4 Therapeutics (C4T) (Nasdaq: CCCC) is a clinical-stage biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of medicines that transforms patients’ lives. C4T is progressing targeted oncology programs through clinical studies and leveraging its TORPEDO® platform to efficiently design and optimize small-molecule medicines to address difficult-to-treat diseases. C4T’s degrader medicines are designed to harness the body’s natural protein recycling system to rapidly degrade disease-causing proteins, offering the potential to overcome drug resistance, drug undruggable targets and improve patient outcomes. For more information, please visit www.c4therapeutics.com .

Job Summary

We are seeking an experienced and highly collaborative Small Molecule Drug Product Formulation specialist to lead the design, early-phase development, and manufacturing scale-up of our oral solid dose drug product candidates. In this role, you will drive the progression of pipeline molecules from initial pre-formulation characterization through successful technology transfer into GMP manufacturing for clinical trials. You will serve as the technical lead overseeing external contract manufacturing organizations, reviewing production records, and continuously optimizing drug product formulations to align with our target product profiles (TPP). This role requires a strong balance of hands-on technical expertise and cross-functional leadership, working in lockstep with internal Discovery, Supply Chain, Quality, and external CDMO partners.

Your Role

• Lead phase-appropriate small molecule drug product formulation development for C4T’s clinical portfolio, applying scientific principles to design, optimize, and scale robust formulations that meet target product profiles, stability requirements, and clinical delivery needs.
• Oversee formulation development, process optimization, scale-up, and technology transfer activities for oral drug products, working closely with external CDMOs and contract manufacturing partners to ensure scalable, GMP-compliant manufacturing processes.
• Direct and evaluate the work of external scientists and suppliers, including vendor identification, RFP technical input, CDMO selection, and review of emerging formulation, manufacturing, and analytical data.
• Provide technical leadership for engineering, clinical, and validation batches by reviewing master batch records, executed production documents, change controls, deviations, and analytical data to ensure alignment with GMP requirements and product specifications.
• Support CMC strategy and regulatory readiness by authoring and reviewing technical memos, specifications, and relevant sections of regulatory filings, including INDs and IMPDs.
• Serve as the drug product technical representative across Discovery, Supply Chain, Quality Assurance, Tech Ops, project management, and external partners, building effective relationships and helping establish efficient process development practices.

Your Background

Required:

• A PhD in in Pharmaceutical Chemistry, Formulation Sciences, or related scientific discipline with a minimum of eight years of post-graduate experience, including time spent in an industry setting with hands-on experience in formulation development, process optimization, scale-up, technology transfer, and manufacturing of solid oral and parenteral dosage forms of small molecules, developing excellent science-based problem-solving and critical-thinking abilities.
• Experience in a cross functional drug product leadership role advancing clinical-stage programs that requires frequent interaction with internal and external stakeholders relevant to early & late-stage product development, with strong written communication skills for authoring regulatory documents.
• Familiarity with quality-by-design (QbD) approaches to drug product development, working knowledge of Good Manufacturing Practices (cGMPs) and Regulatory Guidance Documents as they relate to manufacture and quality testing of pharmaceutical products.
• Experience with creating RFPs, and managing CDMOs performance for formulation development, process optimization, and manufacturing of drug product.
• Ability to multi-task and manage several projects in parallel, interpret and present data to all levels of stakeholders, design tests, and articulate results in an effective manner with a sense of urgency to drive development progress.

Compensation

The base pay range for this position at commencement of employment is expected to be between $230,090.00 and $254,310.00 annually; however, base pay offered may vary depending on multiple individualized factors, including job-related knowledge, skills, and experience.

C4 Therapeutics is an Equal Opportunity Employer.