Senior Engineer, Tangential Flow Filtration (TFF)

Millipore Corporation; Bedford (MA); On-site; USD 117,000 - 178,000; Full time

Benefits offered by this job

Health insurance

PTO

Retirement contributions

Job summary

MilliporeSigma, a business of Merck KGaA, Darmstadt, Germany, seeks a Sr. Engineer to join Process Solutions Filtration R&D at the Bedford, MA campus.

The role centers on Tangential Flow Filtration (TFF) technology for next-generation bioprocessing and involves leading development programs around membranes, modules, and integrated filtration solutions. You will collaborate across Operations, Process Development, Applications, Quality, IP, Regulatory, and Commercial teams; manage scope, timelines

Qualifications

• B.S. in chemical or mechanical engineering with 5–7+ years experience in a related technical area.
• Track record in filtration/bioprocessing product development and validation.
• Experience in project planning, budgeting, risk assessment (FMEA) and post-launch support.
• Ability to collaborate with multiple functions across the organization.

Responsibilities

• Lead technology and product development programs around TFF membranes, modules, materials, devices and integrated filtration solutions for therapeutic biopharmaceutical manufacturing.
• Define technical roadmaps, translate unmet customer needs into scalable TFF concepts, and de-risk through lab and pilot-scale studies.
• Analyze process bottlenecks, evaluate novel TFF concepts/equipment, and design experiments to optimize flux, selectivity, shear, fouling resistance, and cleaning/sterilization compatibility.
• Collaborate cross-functionally with Operations, Process Development, Applications, Quality, IP, Regulatory, and commercial teams to ensure robust, scalable, and defensible filtration solutions.
• Manage project scope, timelines, budgets, and risk (e.g., FMEA); provide post-launch support and iterative improvements.
• Communicate technical results clearly to both technical and non-technical stakeholders; author technical reports, SOPs, and patent/presentation materials as needed.
• Occasional domestic/international travel to support programs and customer engagements.

Skills

TFF technology

Project management

Statistical analysis

Cross-functional collaboration

Lab/pilot-scale experiments

Education

Bachelor’s degree in Chemical/Mechanical engineering

MS in engineering

PhD in engineering

Job description

MilliporeSigma, a business of Merck KGaA, Darmstadt, Germany, seeks a Sr. Engineer to join Process Solutions Filtration R&D at the Bedford, MA campus.

The role centers on Tangential Flow Filtration (TFF) technology for next-generation bioprocessing and involves leading development programs around membranes, modules, and integrated filtration solutions. You will collaborate across Operations, Process Development, Applications, Quality, IP, Regulatory, and Commercial teams; manage scope, timelines