Senior Downstream Scientist: Purification & Tech Transfer

Pfizer; Bothell (WA); On-site; USD 94,000 - 156,000; Full time

Benefits offered by this job

Bonus target 12.5% of base salary

401(k) plan with Pfizer Matching

Comprehensive benefits

Job summary

Pfizer is seeking a Senior Scientist (R4) in Downstream Process Development to advance recovery and purification for recombinant proteins in mammalian culture. You will join a multidisciplinary team across sites working on robust, scalable downstream strategies for early and late-phase programs.

The role requires strong lab experience, independence, and collaboration in a matrix environment, with emphasis on QbD, data interpretation, and regulatory support.

Qualifications

• Bachelor’s degree with 8+ years of relevant experience, or Master’s with 6+ years, or PhD with 0-3 years.
• Hands-on recombinant protein downstream process development, technology transfer, and/or bioprocess manufacturing.
• Strong understanding of protein chemistry and protein analytics; apply current literature.
• Independently drive experimental work, deliver results, and contribute innovative solutions.
• Excellent written and verbal communication skills, including technical documentation.
• Experience using AI tools (e.g., ChatGPT, Copilot) to problem solve and improve productivity.
• Curiosity about responsible AI practices and risk management.

Responsibilities

• Design and execute small-scale downstream studies with pilot-scale/ manufacturing support.
• Analyze data to refine hypotheses on recovery and purification processes.
• Contribute to process characterization, QbD, and regulatory filings.
• Author technical reports and present results to cross-functional teams.
• Identify opportunities for operational efficiency across Bioprocess R&D workflows.
• Support changes to enable pipeline, legacy, and innovation programs.

Skills

Downstream process development

Protein chemistry

Analytical data interpretation

Experimentation leadership

Technical writing

AI tools usage

Collaboration in matrix environment

Education

Bachelor’s degree in biological or engineering discipline

Master’s degree in relevant field

PhD in relevant field

Job description

Pfizer is seeking a Senior Scientist (R4) in Downstream Process Development to advance recovery and purification for recombinant proteins in mammalian culture. You will join a multidisciplinary team across sites working on robust, scalable downstream strategies for early and late-phase programs.

The role requires strong lab experience, independence, and collaboration in a matrix environment, with emphasis on QbD, data interpretation, and regulatory support.