Senior Modeling & Simulations Leader, Drug Development

Vertex Pharmaceuticals Inc (US); United States; Hybrid; USD 168,000 - 252,000; Full time

Benefits offered by this job

Hybrid-Eligible

Annual bonus

Equity awards

Job summary

Vertex Pharmaceuticals is seeking a Modeling & Simulations Associate Director to lead cross-functional drug development teams with PK/PD modeling, population PK analyses, and clinical trial simulations. You will develop M&S plans, execute analyses, and influence decision-making with state-of-the-art methods.

We value deep expertise in PKPD, leadership, and collaboration across Clinical Pharmacology, Biostatistics, and Research. A PhD or MSc in a quantitative field is preferred.

Qualifications

• PhD or MSc with strong pharmacometrics and PKPD modeling experience.
• Advanced knowledge of population PK/PKPD modeling and disease progression.
• Experience in clinical development teams and decision support.
• Proficiency with PK/PD modeling tools and programming skills.

Responsibilities

• Lead M&S plans and analyses integrated with development plans.
• Perform mechanism-based PKPD and population PK analyses.
• Run clinical trial simulations to inform dose selection.
• Support training and adopt new M&S tools.
• Collaborate across Clinical Pharmacology, Biostatistics and Research.

Skills

Population PK

PKPD modeling

Clinical trial simulations

Model-based analyses

Leadership

Communication skills

Collaborative skills

Education

PhD in Pharmaceutical sciences / Pharmacometrics

Tools

NonMem

PsN

R

Phoenix

Job description

Vertex Pharmaceuticals is seeking a Modeling & Simulations Associate Director to lead cross-functional drug development teams with PK/PD modeling, population PK analyses, and clinical trial simulations. You will develop M&S plans, execute analyses, and influence decision-making with state-of-the-art methods.

We value deep expertise in PKPD, leadership, and collaboration across Clinical Pharmacology, Biostatistics, and Research. A PhD or MSc in a quantitative field is preferred.