Senior DMPK Modeler — Translational PK/PD Expert

Vividion Therapeutics, Inc; San Diego (CA); On-site; USD 130,000 - 175,000; Full time

Benefits offered by this job

401k with company match

Medical, dental, vision insurance

Disability insurance

Job summary

Vividion Therapeutics, Inc. in San Diego is seeking a DMPK Modeling & Simulation Scientist to apply quantitative approaches to drug disposition, PK/PD, and translational modeling.

You will integrate in vitro, in vivo, and clinical data to inform candidate selection, dose design, and decision-making across project teams. Depending on experience, you may lead modeling activities and serve as a translational partner to multidisciplinary teams, connecting preclinical findings with clinical

Qualifications

• Strong understanding of systems biology, physiology, PK/PD principles.
• Expertise in differential equation-based modeling and parameter estimation/optimization.
• Hands-on scripting in R, Python, etc.
• Experience with PBPK platforms and translational modeling.
• Ability to influence project strategy through quantitative decision-making.
• Excellent communication and cross-functional collaboration skills.

Responsibilities

• Build and apply fit-for-purpose mechanistic and translational models (PBPK, PK/PD, TE) to support discovery and development programs.
• Integrate in vitro, in vivo, and clinical data using modeling to support first in human dose projections, study design, regulatory submissions, and clinical pharmacology modeling.
• Characterize relationships among exposure, target engagement, pharmacodynamic response, efficacy, and safety to inform dose selection.
• Assess impact of formulation, absorption, metabolism, transporters, and DDIs on pharmacokinetics.
• Evaluate variability and uncertainty in PBPK, PK/PD, and TE predictions to support program decisions.
• Present findings to project teams, governance committees, and external collaborators.

Skills

PBPK modeling

PK/PD modeling

Differential equations

Python

R programming

IND filings

Regulatory guidance

Cross-functional collaboration

Education

Master's or PhD in Pharmacokinetics or related field

Tools

GastroPlus

Simcyp

PK-Sim

Job description

Vividion Therapeutics, Inc. in San Diego is seeking a DMPK Modeling & Simulation Scientist to apply quantitative approaches to drug disposition, PK/PD, and translational modeling.

You will integrate in vitro, in vivo, and clinical data to inform candidate selection, dose design, and decision-making across project teams. Depending on experience, you may lead modeling activities and serve as a translational partner to multidisciplinary teams, connecting preclinical findings with clinical