Director, Translational PK & PBPK Modeling

Lilly; Boston (MA); Remote; USD 177,000 - 284,000; Full time

Benefits offered by this job

401(k) plan

Pension

Medical, dental, vision

Flexible spending accounts

Life insurance

Vacation benefits

Well-being benefits

ERGs

Job summary

Centessa Pharmaceuticals, a Lilly subsidiary, seeks an experienced Director, Translational Pharmacokinetics – DMPK to lead PK modeling for early-stage programs. You will develop PBPK and PKPD models to simulate ADME and DDI, integrate in vitro and in vivo data, and support FIH dose projections in collaboration with cross-functional teams.

The ideal candidate has a PhD or PharmD with 12+ years in PBPK/PKPD, IND-enabling experience, and proficiency in Simcyp, GastroPlus, Phoenix WinNonlin, and

Qualifications

• PhD, PharmD, or equivalent advanced scientific degree.
• 12+ years of industry experience in PBPK/PKPD modeling and FIH dose projections.
• Experience supporting IND-enabling programs and regulatory submissions.
• Solid understanding of ADME principles.

Responsibilities

• Model development: design and implement PBPK models for drug behavior.
• Data integration: combine pharmacokinetics and pharmacodynamics data.
• Regulatory support: provide simulations for INDs, CTAs, and related submissions.
• Collaboration: work with cross-functional teams to validate models.
• Scenario analysis: run DDI simulations and optimize dosing strategies.
• Pipeline progression: support candidate selection and transition to development.
• Scientific leadership: present findings to leadership and mentor scientists.

Skills

Biostatistics

PK modeling

IND-enabling

Regulatory submissions

Cross-functional collaboration

Education

PhD or PharmD

Tools

Simcyp

GastroPlus

Phoenix WinNonlin

NONMEM

Job description

Centessa Pharmaceuticals, a Lilly subsidiary, seeks an experienced Director, Translational Pharmacokinetics – DMPK to lead PK modeling for early-stage programs. You will develop PBPK and PKPD models to simulate ADME and DDI, integrate in vitro and in vivo data, and support FIH dose projections in collaboration with cross-functional teams.

The ideal candidate has a PhD or PharmD with 12+ years in PBPK/PKPD, IND-enabling experience, and proficiency in Simcyp, GastroPlus, Phoenix WinNonlin, and