Senior Director, Statistical Programming – Oncology & Submissions

tangotherapeutics; Boston (MA); On-site; USD 172,000 - 258,000; Full time

Job summary

Tango Therapeutics is seeking an Associate Director, Statistical Programming to lead study-specific statistical programming, maintain infrastructure, and ensure SOP compliance for timely, high-quality outputs. This role reports to the Senior Director of Statistical Programming and sits on the Biostatistics team.

You will develop SDTM/ADaM analyses, validate datasets, and support regulatory submissions (FDA/EMA). Collaboration with statisticians, data managers, and CROs is essential.

Qualifications

• Bachelor's or Master's degree in statistics, life sciences, computer science, or related field.
• At least 8 years' statistical programming experience in clinical trials.
• Expert SAS programming (Base, Macro, STAT, GRAPH, SQL) with CDISC SDTM/ADaM experience.
• Experience with R and Python.
• Experience managing CROs.
• Experience with eCTD electronic submissions.

Responsibilities

• Lead and manage statistical programming for trials and CSR.
• Develop, validate, and maintain SDTM/ADaM datasets, tables, listings, and figures.
• Review key clinical study or program documents.
• Perform complex statistical analyses and simulations using SAS; manage macro library and templates.
• Provide expertise in regulatory submissions (FDA/EMA, eCTD).
• Collaborate with biostatisticians and data managers to define programming strategies.

Skills

Statistical programming

Leadership

Regulatory submissions

Cross-functional collaboration

Education

Bachelor's or Master's degree in statistics, life sciences, computer science, or related field

Tools

SAS

R

Python

CDISC SDTM/ADaM

Job description

Tango Therapeutics is seeking an Associate Director, Statistical Programming to lead study-specific statistical programming, maintain infrastructure, and ensure SOP compliance for timely, high-quality outputs. This role reports to the Senior Director of Statistical Programming and sits on the Biostatistics team.

You will develop SDTM/ADaM analyses, validate datasets, and support regulatory submissions (FDA/EMA). Collaboration with statisticians, data managers, and CROs is essential.