Associate Director, Statistical Programming

Tango Therapeutics, Inc; Boston (MA); On-site; USD 172,000 - 258,000; Full time

Job summary

Tango Therapeutics, Inc. is seeking an Associate Director, Statistical Programming to lead and manage programming activities for clinical trials. The role develops SDTM/ADaM datasets and TLFs, validates analyses, and supports regulatory submissions under CDISC standards.

The position requires expert SAS skills, experience with SDTM/ADaM, and collaboration with biostatisticians and CROs. Oncology background and BLA/NDA experience are a plus.

Qualifications

• Minimum 8 years of statistical programming experience.
• Strong regulatory reporting experience including eCTD and CDISC implementations.
• Expert level SAS programming skills (Base, Macro, STAT, GRAPH, SQL).
• Experience with R and Python.
• Experience in oncology and with BLA/NDA submissions to FDA/EMA is preferred.

Responsibilities

• Lead and manage statistical programming activities for clinical trials and studies, ensuring high-quality, timely deliverables.
• Develop, validate, and maintain SDTM/ADaM datasets, tables, listings, and figures (TLFs).
• Review key study documents and provide regulatory-compliant analysis.
• Perform complex statistical analyses and simulations using SAS; manage macro library for efficiency.
• Provide SAS programming support for regulatory submissions (eCTD).
• Collaborate with biostatisticians, data managers, and cross-functional teams to define strategies and timelines.
• Oversee CROs to ensure quality and timeliness of analyses and deliverables.
• Author/review SDTM/ADaM specifications; stay current with industry trends and best practices.

Skills

SAS programming (Base/Macro/STAT/GRAPH

CDISC SDTM/ADaM

eCTD regulatory submissions

CRO management

R

Python

Data governance

Statistical analysis

Education

Bachelor’s or Master’s degree in statistics/life sciences/computer science

Tools

SAS

R

Python

Job description

Associate Director, Statistical Programming

Company Overview

Tango Therapeutics is a clinical-stage biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

Tango's labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary

Tango has an exciting opportunity to join our growing Biostatistics team as an Associate Director, Statistical Programming, reporting to the Senior Director of Statistical Programming. In this role, you will be responsible for study-specific statistical programming activities, maintaining programming infrastructure, and ensuring compliance with SOPs to deliver high-quality, timely outputs.

Your Role

• Lead and manage the statistical programming activities for clinical trials and studies, ensuring high-quality and timely deliverables for CSR, publications, presentations, various reports for health authority submissions, clinical data review, and ad hoc analysis either internally or through CRO partners
• Develop, validate, and maintain analysis datasets (SDTM, ADaM), tables, listings, and figures, TLFs) in accordance with regulatory guidelines and internal standards
• Review key clinical study or program documents
• Perform complex statistical analyses and simulations using SAS to support clinical trial design and data interpretation; manage macro library and templates for efficiently preparing, processing, analyzing clinical data and validating analysis results
• Provide expertise in statistical programming for regulatory submissions (e.g., FDA, EMA), including electronic submission standards (eCTD)
• Participate in Tango’s Data Governance Team to build and maintain secure statistical computing and programming infrastructure
• Collaborate with biostatisticians, data managers, and cross-functional team members to define programming strategies and requirements, establish project timelines, and perform statistical analyses
• Manage and provide oversight of CROs to ensure high-quality statistical analysis deliverables (datasets, TLFs, etc.) within timeline and budget
• Author or Review SDTM and ADaM specifications to ensure compliance to CDISC standards
• Review key clinical study or program documents
• Develop SAS code, manage macro library and templates for efficiently preparing, processing, analyzing clinical data, and validating analysis results
• Author and/or review statistical analysis related SOPs
• Stay current with industry trends, best practices, and emerging technologies in statistical programming and data analysis
• Additional duties and responsibilities as required

What You Bring

• Bachelor’s or Master’s degree in statistics, life sciences, computer science, or related field with at least 8 years’ statistical programming experience
• Solid understanding of industry standards applicable to clinical study data and regulatory reporting requirements including eCTD and CDISC implementation
• Expert level expertise in SAS programming (Base, Macro, STAT, GRAPH, SQL) is essential; with experience delivering complex programming assignments, macros, and analyses
• Experience with R and Python
• Extensive experience in early-phase clinical studies including programming and validation of SDTM and ADaM data sets, tables, listings and figures
• Experience managing CROs for outsourced statistical programming activities
• Expertise in the requirements and technology to support electronic submissions
• Experience in oncology preferred
• Experience with BLA or NDA/sNDA submissions to FDA/EMA required
• Strong analytical and communication skills

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Salary range

$172,000 - $258,000 USD

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey.Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiringprocess or thereafter. Any information that you do provide will be recorded and maintained in aconfidential file.

As set forth in Tango Therapeutics’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law.

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection.As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measurethe effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categoriesis as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.