Senior Director, LNP Formulation & Process Innovation

Flagship Pioneering; Cambridge (MA); On-site; USD 213,000 - 281,000; Full time

Job summary

Mirai Bio in Cambridge, MA, seeks a Senior Director of Lipid Nanoparticle (LNP) Formulation & Process Development to lead the LNP formulation, process development, and small-scale production across partner and internal programs.

The role combines scientific leadership with client-facing responsibilities, shaping development strategy, ensuring quality and scalability, mentoring a scientific team, and collaborating with Analytical Development, Translational Biology, and Project Management.

Qualifications

• PhD with 12+ years in industry; MS with 14+ years; or BS with 16+ years.
• Extensive hands-on LNP formulation and process development.
• Strong leadership of scientific teams.
• Excellent client-facing communication.

Responsibilities

• Lead the LNP formulation, process development, and small-scale production function supporting partner and internal programs.
• Establish technical strategy and best practices for LNP formulation, process development, characterization, and production across multiple payloads and applications.
• Provide senior technical leadership across multiple programs, including development strategy, experimental planning, data review, risk mitigation, and technical recommendations.
• Serve as a senior technical interface with clients and partners and support proposals, project scopes, presentations, and business development activities.
• Oversee non-GMP production of LNP formulations for in vitro, in vivo, and preclinical studies.
• Drive technical troubleshooting, process optimization, technology transfer, and continuous improvement of LNP production for mRNA, siRNA, gene-editing components, and other nucleic acid payloads.
• Establish workflows, documentation, and operational practices that improve quality, reproducibility, efficiency, and scalability.
• Lead, mentor, and develop the LNP team while managing priorities, resources, capacity, and organizational growth.
• Collaborate cross-functionally to align LNP development and production with broader program and company objectives.

Skills

LNP formulation

Process development

Team leadership

Client-facing

Education

PhD in Pharmaceutical Sciences

MS in related field

BS in related field

Tools

Tech transfer

Non-GMP production

Scale-up capabilities

Job description

Mirai Bio in Cambridge, MA, seeks a Senior Director of Lipid Nanoparticle (LNP) Formulation & Process Development to lead the LNP formulation, process development, and small-scale production across partner and internal programs.

The role combines scientific leadership with client-facing responsibilities, shaping development strategy, ensuring quality and scalability, mentoring a scientific team, and collaborating with Analytical Development, Translational Biology, and Project Management.