Senior Director, Clinical Pharmacology & MIDD Leadership

Madrigal; Conshohocken (Montgomery County); On-site; USD 228,000 - 264,000; Full time

Job summary

Madrigal is seeking an experienced Clinical Pharmacologist to provide strategic leadership for clinical pharmacology across all drug development stages. You will develop integrated Pharmacology strategies, guide dose selection, characterize PK/PD, and support regulatory submissions.

The role emphasizes model-informed drug development (MIDD), collaboration with multidisciplinary teams, and engagement with health authorities to enable informed decision making and registration.

Qualifications

• Advanced degree in pharmacology, pharmaceutical sciences, biomedical engineering or related field preferred.
• PhD/PharmD or equivalent required for senior level.
• Experience across PK/PD, dose selection, and regulatory submissions.

Responsibilities

• Develop integrated Clinical Pharmacology strategies across all development stages.
• Represent Clinical Pharmacology in development teams and regulatory interactions.
• Lead dose selection and explore exposure–response analyses.
• Oversee Phase 1 studies and associated data interpretation.
• Contribute to MIDD strategy and vendor management.
• Prepare regulatory submissions (IND/NDA/BLA/MAA).

Skills

Clinical Pharmacology

Pharmacokinetics

Pharmacodynamics

MIDD

Regulatory submissions

Stakeholder management

Data analysis

Team leadership

Education

PhD or PharmD or equivalent

Tools

NONMEM

R

Monolix

Phoenix WinNonlin

Job description

Madrigal is seeking an experienced Clinical Pharmacologist to provide strategic leadership for clinical pharmacology across all drug development stages. You will develop integrated Pharmacology strategies, guide dose selection, characterize PK/PD, and support regulatory submissions.

The role emphasizes model-informed drug development (MIDD), collaboration with multidisciplinary teams, and engagement with health authorities to enable informed decision making and registration.