Associate Director, Clinical Pharmacology – MIDD Leader

City Therapeutics; Cambridge (MA); On-site; USD 174,000 - 196,000; Full time

Job summary

City Therapeutics in Cambridge, MA is seeking an Associate Director of Clinical Pharmacology to lead PK/PD strategies across RNAi programs. You will design and interpret MIDD approaches, drive dose selection, and collaborate with cross-functional teams to advance development from FIH to late-stage trials.

The role reports to the Head of CPPK and requires strong regulatory collaboration and experience with exposure–response analyses and regulatory submissions.

Qualifications

• PhD/PharmD/MD or equivalent in Clinical Pharmacology or related field.
• 7+ years of industry experience in clinical pharmacology or pharmacometrics.
• Experience leading pharmacology activities across multiple programs and regulatory interactions.
• Experience with population PK and exposure–response analyses for dose recommendation.

Responsibilities

• Lead development and execution of clinical pharmacology strategies for RNAi programs.
• Conduct model-informed drug development and PK/PD analyses to support regulatory interactions.
• Contribute to protocol design, SAPs, trial reports, and regulatory documents.
• Collaborate across regulatory, clinical, and translational teams to drive decisions.
• Develop dose selection and optimization strategies for development programs.

Skills

Model-informed drug development

Population PK

Exposure–response

PK/PD modeling

Regulatory interactions

Cross-functional leadership

Communication skills

CRO/vendor collaboration

Oligonucleotide therapeutics

Education

PhD, PharmD, MD or equivalent advanced degree in relevant field

Job description

City Therapeutics in Cambridge, MA is seeking an Associate Director of Clinical Pharmacology to lead PK/PD strategies across RNAi programs. You will design and interpret MIDD approaches, drive dose selection, and collaborate with cross-functional teams to advance development from FIH to late-stage trials.

The role reports to the Head of CPPK and requires strong regulatory collaboration and experience with exposure–response analyses and regulatory submissions.