Senior Clinical Trials Manager – Oncology & Global Programs

Regulatory Jobs; Boston (MA); On-site; USD 120,000 - 180,000; Full time

Job summary

Tango Therapeutics in Boston, MA is seeking a Clinical Trial Manager to lead operational aspects of clinical trials and support the Clinical Trial Leader. This role acts as a core member of the Clinical Trial Team and communicates with CROs and vendors to ensure timely, compliant execution.

The candidate will set up trial systems, monitor performance, manage budgets, and coordinate site management in trials with or without a Site Management Lead. Travel is expected (10–20%).

Qualifications

• 5+ years of trial management experience.
• Bachelor’s degree in Life Sciences or related field.
• Experience working in global clinical development organization.
• Experience in Oncology development (preferred).
• Direct experience with health authority inspections (FDA, EMA, MHRA, etc.) incl. sponsor GCP inspections (preferred).
• Experience in outsourcing and oversight.
• Knowledge of ICH-GCP, FDA guidelines, EU CTR and other relevant guidelines.
• Knowledge of financial planning, tracking, and reporting.
• Knowledge of trial risk assessment and management.
• Familiarity with clinical trial systems (e.g., CTMS, eTMF, EDC, IRT, eCOA) and site management metrics, KPIs, and KRIs.

Responsibilities

• Serve as a core member of the Clinical Trial Team (CTT) and act as deputy for the Clinical Trial Leader (CTL) during absences.
• Organize and coordinate CTT meetings, including preparing agendas, recording minutes, and tracking follow-up actions.
• Facilitate communication and collaboration within the team and with external partners such as CROs and vendors.
• Contribute to the development and maintenance of trial-level documents and operational plans, including project management, communication, risk management, and quality plans.
• Establish and manage trial-related systems and processes (e.g., central laboratories, eCOA/ ePRO) in alignment with protocol requirements.
• Monitor CRO/ vendor performance and ensure timely and accurate data integration, transfer, and reconciliation.
• Identify risks and issues and support the development and implementation of mitigation strategies and action plans.
• Maintain accurate and up-to-date trial information in systems and communication tools.
• Set up and maintain clinical trial insurance in participating countries.
• Coordinate with the global supply chain to ensure timely supply and distribution of devices and investigational medicinal products, comparator or co-medication to clinical sites.
• Prepare and distribute trial-related correspondence and contribute to the development of materials for meetings, newsletters, and websites.
• Lead logistical arrangements and support content development for external meetings such as investigator meetings and advisory boards.
• Ensure ongoing inspection and audit readiness. Participate in internal audits and regulatory inspections, as required.
• Support budget forecasting and accrual processes. Assist with invoice tracking, and processing in line with vendor contracts.
• Act as CTL when assigned, leading cross-functional CTT to operationalize the protocol of a clinical trial.
• Lead the development of site management oversight plan and ensure site management oversight including risk management for trials without assigned Site Management Lead (SML).

Skills

Trial management

Leadership

Cross-functional leadership

Vendor management

Regulatory inspections

Clinical operations

Education

Bachelor’s degree in Life Sciences, Pharmacy or related field

Experience in oncology development (preferred)

Tools

CTMS

eTMF

EDC

IRT

eCOA

Job description

Tango Therapeutics in Boston, MA is seeking a Clinical Trial Manager to lead operational aspects of clinical trials and support the Clinical Trial Leader. This role acts as a core member of the Clinical Trial Team and communicates with CROs and vendors to ensure timely, compliant execution.

The candidate will set up trial systems, monitor performance, manage budgets, and coordinate site management in trials with or without a Site Management Lead. Travel is expected (10–20%).