Senior Clinical Data Manager — Hybrid Oversight

Tango Therapeutics; Boston (MA); On-site; USD 145,000 - 217,000; Full time

Benefits offered by this job

Hybrid work model

Job summary

Tango Therapeutics, based in Boston, seeks a Senior Manager, Clinical Data Management to lead data management activities from startup through database lock and closeout, ensuring high-quality, inspection-ready data and sponsor alignment across trials.

You will oversee CROs and vendors, manage EDC/IRT/eCOA programs, review key deliverables, establish data quality metrics, and support regulatory submissions in a fast-paced oncology setting.

Qualifications

• Bachelor's degree required
• 5+ years Clinical Data Management in biotech/pharma/CRO
• Experience overseeing outsourced Data Management
• Experience with EDC, IRT, eCOA systems
• Knowledge of CDISC standards (CDASH/SDTM)
• Familiarity with regulatory compliance and audits

Responsibilities

• Lead DM activities from study startup through database lock and closeout
• Oversee CROs and external vendors, ensuring quality, timelines, and regulatory compliance
• Ensure timely, complete, and inspection-ready data (EDC, IRT, eCOA, data cleaning)
• Review key DM deliverables (CRF/eCRF, specifications, data transfer, reconciliation)
• Establish data quality metrics and data review strategies
• Support regulatory submissions and inspections as required

Skills

CDISC CDASH/SDTM

EDC Systems

Vendor Oversight

Regulatory Knowledge

Data Quality

GCP/FDA

Cross-functional

Risk Management

Project Management

Education

Bachelor's degree in Computer Science, Life Sciences, Mathematics, Health Sciences, or related field

Job description

Tango Therapeutics, based in Boston, seeks a Senior Manager, Clinical Data Management to lead data management activities from startup through database lock and closeout, ensuring high-quality, inspection-ready data and sponsor alignment across trials.

You will oversee CROs and vendors, manage EDC/IRT/eCOA programs, review key deliverables, establish data quality metrics, and support regulatory submissions in a fast-paced oncology setting.