Clinical Trial Manager - Oncology Global Operations

Tango Therapeutics, Inc; Boston (MA); On-site; USD 120,000 - 180,000; Full time

Job summary

Tango Therapeutics, Inc. is seeking a Clinical Trial Manager (CTM) to lead operational aspects of clinical trials and support the Clinical Trial Leader.

This role functions as a key member of the Clinical Trial Team and primary contact for external partners and vendors, with potential to lead cross-functional teams for smaller trials or manage critical aspects of larger trials. In a fast-paced biotech environment, you will oversee study setup, conduct, data integration, risk management, and

Qualifications

• 5+ years of trial management experience
• Leadership experience preferred
• Experience working in global clinical development organization
• Experience in Oncology development preferred
• Direct experience with health authority inspections (FDA, EMA, MHRA, etc.) incl. sponsor GCP inspections preferred
• Experience in outsourcing and oversight
• Knowledge of ICH-GCP, FDA guidelines, EU CTR and other relevant guidelines
• Knowledge of financial planning, tracking, and reporting
• Knowledge of trial risk assessment and management
• Familiarity with clinical trial systems (e.g., CTMS, eTMF, EDC, IRT, eCOA) and site management metrics, KPIs, and KRIs
• Strong vendor management and project management skills
• Leadership skills with the ability to lead cross-functional teams
• Strong interpersonal and communication skills
• Strong analytical thinking and decision-making capabilities
• Willingness to travel, as required (typically 10–20%)

Responsibilities

• Serve as a core member of the Clinical Trial Team (CTT) and act as deputy for the Clinical Trial Leader (CTL) during absences
• Organize and coordinate CTT meetings, including preparing agendas, recording minutes, and tracking follow-up actions
• Facilitate communication and collaboration within the team and with external partners such as CROs and vendors
• Contribute to the development and maintenance of trial-level documents and operational plans, including project management, communication, risk management, and quality plans
• Establish and manage trial-related systems and processes (e.g., central laboratories, eCOA/ ePRO) in alignment with protocol requirements
• Monitor CRO/ vendor performance and ensure timely and accurate data integration, transfer, and reconciliation. Escalate issues to the CTL, as needed
• Identify risks and issues and support the development and implementation of mitigation strategies and action plans
• Maintain accurate and up-to-date trial information in systems and communication tools
• Set up and maintain clinical trial insurance in participating countries
• Coordinate with the global supply chain to ensure timely supply and distribution of devices and investigational medicinal products, comparator or co-medication to clinical sites
• Prepare and distribute trial-related correspondence and contribute to the development of materials for meetings, newsletters, and websites
• Lead logistical arrangements and support content development for external meetings such as investigator meetings and advisory boards
• Ensure ongoing inspection and audit readiness. Participate in internal audits and regulatory inspections, as required
• Support budget forecasting and accrual processes. Assist with invoice tracking, and processing in line with vendor contracts
• Act as CTL when assigned, leading cross-functional CTT to operationalize the protocol of a clinical trial
• Lead the development of site management oversight plan and ensure site management oversight including risk management for trials without assigned Site Management Lead (SML)

Skills

Trial management experience

Leadership experience

Global clinical development experience

Oncology development experience

Health authority inspections

Outsourcing and oversight

ICH-GCP & FDA guidelines knowledge

Financial planning, tracking & reports

Risk assessment & management

Clinical trial systems familiarity

Vendor management

Cross-functional leadership

Interpersonal & communication skills

Willingness to travel

Education

Bachelor’s degree in Life Sciences, Pharmacy or related field

Tools

CTMS

eTMF

EDC

IRT

eCOA

Job description

Tango Therapeutics, Inc. is seeking a Clinical Trial Manager (CTM) to lead operational aspects of clinical trials and support the Clinical Trial Leader.

This role functions as a key member of the Clinical Trial Team and primary contact for external partners and vendors, with potential to lead cross-functional teams for smaller trials or manage critical aspects of larger trials. In a fast-paced biotech environment, you will oversee study setup, conduct, data integration, risk management, and