Senior Clinical Data Manager: Lead Trial Data & Compliance

Tango Therapeutics, Inc; Boston (MA); On-site; USD 145,000 - 217,000; Full time

Job summary

Tango Therapeutics, Inc. is seeking a Senior Manager, Clinical Data Management to lead data management activities across assigned trials. You will ensure high-quality, inspection-ready data and oversee CROs, IRT, and eCOA vendors to support trial execution and regulatory submissions.

You will collaborate with Biostatistics, Regulatory Affairs, and Clinical Operations to maintain data integrity, drive continuous improvement, and ensure compliance with ICH-GCP, FDA, and CDISC standards.

Qualifications

• Bachelor's degree in a relevant field (Computer Science, Life Sciences, or related).
• 5+ years of Clinical Data Management experience in biotech/pharma/CRO.
• Experience leading Data Management in regulated trials.

Responsibilities

• Serve as the Data Management lead within the Clinical Trial Team and oversee Data Management activities across the trial lifecycle.
• Provide sponsor oversight of CROs and external vendors, ensuring DM, IRT, and eCOA activities meet requirements, quality, and timelines.
• Ensure timely delivery of complete, accurate, inspection-ready data through oversight of outsourced DM activities (EDC, IRT, eCOA).
• Review and approve key DM deliverables (CRF/eCRF, IRT, eCOA specs, data transfer specs).
• Establish data quality metrics, KPIs, and data review strategies for data integrity and regulatory compliance.

Skills

Clinical Data Management

Vendor oversight

Regulatory knowledge

CDISC (CDASH/SDTM)

EDC systems

UAT

Data integration

Project management

Cross-functional collaboration

Risk management

Problem-solving

Communication

Education

Bachelor's degree in Computer Science

Bachelor's degree in Life Sciences

Tools

EDC platforms

IRT

eCOA

Job description

Tango Therapeutics, Inc. is seeking a Senior Manager, Clinical Data Management to lead data management activities across assigned trials. You will ensure high-quality, inspection-ready data and oversee CROs, IRT, and eCOA vendors to support trial execution and regulatory submissions.

You will collaborate with Biostatistics, Regulatory Affairs, and Clinical Operations to maintain data integrity, drive continuous improvement, and ensure compliance with ICH-GCP, FDA, and CDISC standards.