Senior Chemical Development Scientist – Oligonucleotides

Novo Nordisk A/S; Boulder (CO); On-site; USD 70,000 - 105,000; Full time

Benefits offered by this job

Health, dental and vision coverage

401(k) plan with company match

Tuition reimbursement

Flexible spending accounts

Job summary

Novo Nordisk is seeking a Senior Research Associate to join the GNAT Chemical Development team in Boulder, CO. The role focuses on developing scalable syntheses, work-up, purifications and isolations of oligonucleotides, with emphasis on purity, yield, reproducibility and environmental impact.

The successful candidate will have a strong organic chemistry background with exposure to process development and tech transfer into manufacturing, and will independently execute diverse oligonucleotide

Qualifications

• BA/BS degree in Chemistry, Biology or related field with 2+ years, or Master’s degree with 0+ years of relevant industrial experience, or a High School Diploma with 10+ years relevant lab experience
• Ability to follow technical instructions of moderate complexity with independence and reduced supervision
• Demonstratable laboratory skills in synthetic organic chemistry and/or oligonucleotide synthesis, characterization and purification
• Solid understanding of synthetic organic chemistry and/or oligonucleotide relevant reactions and mechanisms
• Detail-oriented in both data analysis and project timelines
• Self-motivated with a proactive mindset
• The successful candidate must possess excellent writing and communication skills and a demonstrated ability to work independently and with cross-functional teams
• Ability to thrive in a multi-disciplinary and fast-paced research environment with tight deadlines

Responsibilities

• Provide R&D support for current chemical development projects utilizing state-of-the-art techniques for preparation and analysis of oligonucleotides or nucleic acids
• Conduct laboratory work in safe, clean, efficient manner that ensures a safe working environment for colleagues
• Characterize starting materials, intermediates and synthesized molecules using techniques such as HPLC, LCMS, NMR, GC, KF and UV-Vis
• Develop and optimize all elements of chemical transformations including reaction conditions, workup, purification and isolation; ensure robustness and reproducibility of developed processes
• Work within Technical Operations team to develop & optimize manufacturing processes for key oligonucleotide intermediates/reagents for oligonucleotide synthesis and final API
• Document and summarize results in laboratory notebook and written reports; capable of drawing valid conclusions from variables
• Contribute to the team’s knowledge through scientific literature review and discussions
• Operate, maintain and troubleshoot common laboratory equipment
• Authoring of development and research reports to share with internal and external teams with reduced input
• Ability to complete assignments that meet clearly defined deadlines and time schedules with minimal instructions.

Skills

Laboratory skills

Analytical techniques

Independent work

Communication skills

Education

BA/BS in Chemistry/Biology or related field

Master's degree in a relevant field

High School Diploma with 10+ years lab experience

Tools

HPLC

LCMS

NMR

GC

KF

UV-Vis

Job description

Novo Nordisk is seeking a Senior Research Associate to join the GNAT Chemical Development team in Boulder, CO. The role focuses on developing scalable syntheses, work-up, purifications and isolations of oligonucleotides, with emphasis on purity, yield, reproducibility and environmental impact.

The successful candidate will have a strong organic chemistry background with exposure to process development and tech transfer into manufacturing, and will independently execute diverse oligonucleotide