Scientist

Hongene Biotech Corporation; Union City (CA); In loco; USD 75.000 - 95.000; Tempo pieno

Descrizione del lavoro

Hongene Biotech Corporation is hiring a Scientist specializing in Oligonucleotide Synthesis in Union City, CA. The role encompasses synthesis, purification, characterization, and process optimization for customer, CRO, and internal projects.

You will design experiments, interpret data, and drive improvements with support from senior scientists. You will work on establishing robust, scalable processes, troubleshooting chemistry challenges, and collaborating across QC, Chemistry/R&D, and

Competenze

• BS/MS in Chemistry or related with oligonucleotide experience (BS 5+ yrs; MS 3+ yrs); PhD typically Sr.
• Hands-on oligonucleotide synthesis and solid-phase chemistry experience.
• Experience in purification methods and analytical characterization of oligos.
• Proficiency with HPLC/UPLC, ÄKTA chromatography systems, and LC-MS.
• Strong troubleshooting and collaborative work style.
• Ability to work on-site in Union City, California.

Mansioni

• Synthesize DNA/RNA and modified oligos; optimize yield and scale.
• Support process scale-up and material generation for projects.
• Perform synthesis preparation, cleavage, deprotection, and processing.
• Maintain accurate records and report progress with QC, Chemistry/R&D, and manufacturing.
• Operate and maintain oligonucleotide synthesizers and chromatography systems.
• Prepare technical reports and communicate risks.
• Collaborate with cross-functional teams and share know-how.

Conoscenze

Oligonucleotide synthesis

Solid-phase synthesis

Phosphoramidite chemistry

HPLC/UPLC

LC-MS

Analytical characterization

Troubleshooting

Cross-functional collaboration

Laboratory operations

Formazione

Bachelor's degree in Chemistry or related

Master's degree in Chemistry or related

PhD in related field (advantage)

Strumenti

ÄKTA chromatography systems

RP-HPLC

UPLC

LC-MS

Descrizione del lavoro

If you are unable to complete this application due to a disability, contact this employer to ask for an accommodation or an alternative application process.

Scientist

Oligonucleotide R&D Full Time Union City, CA, US

Salary Range: $75,000.00 To $95,000.00 Annually

Scientist - Oligonucleotide Synthesis

Pay Range: $75,000-$95,000 per year

Since our founding in 1998, Hongene has been at the forefront of nucleic acid chemistry, earning global recognition for delivering high-purity building blocks that powered the early development of RNA therapeutics. Over the years, we have expanded beyond raw materials to become a trusted CDMO partner for oligonucleotide and mRNA medicines. Through sustained investment in infrastructure, talent, and innovation, we continue to scale cutting-edge science - helping our partners advance the next generation of nucleic acid therapeutics from discovery to market.

About the Role

As a Scientist - Oligonucleotide Synthesis, you will support oligonucleotide synthesis, purification, characterization, process optimization, and scale-up for customer, CRO, and internal projects. Reporting to a Staff Scientist, you'll develop robust, scalable processes, troubleshoot chemistry challenges, and work across teams to move projects forward.

You' ll work independently day to day — designing experiments, interpreting data, and driving improvements — with experienced senior scientists available when a problem calls for a second opinion.

What You' ll Do

Oligonucleotide Synthesis and Process Development

• Perform and optimize solid-phase synthesis of DNA, RNA, and chemically modified oligonucleotides to improve yield, quality, reproducibility, and scalability.
• Support process scale-up and material generation for customer, research, and internal projects.
• Perform synthesis preparation, cleavage, deprotection, and related downstream processing.
• Complete assigned work accurately and within project and customer timelines.

Purification and Analytical Characterization

• Develop purification methods using RP-HPLC, IEX-HPLC, and other relevant techniques, including ÄKTA chromatography systems.
• Apply HPLC/UPLC, LC-MS, and related analytical methods to assess product identity, purity, and impurity profiles.
• Submit samples to QC in accordance with established procedures.

Process Optimization and Troubleshooting

• Investigate synthesis failures, side reactions, and purification challenges through root-cause analysis.
• Design experiments and implement data-driven solutions to improve process robustness, recovery, and reproducibility.
• Seek input from senior scientists on complex or unfamiliar problems.

Equipment and Laboratory Operations

• Operate, maintain, and troubleshoot automated oligonucleotide synthesizers, chromatographic systems, and associated laboratory equipment.
• Maintain safe and efficient laboratory operations, following SOPs, PPE requirements, and hazardous-waste procedures.

Technical Documentation and Communication

• Maintain accurate laboratory records and prepare technical reports, presentations, and scientific documentation.
• Collaborate with cross-functional teams, including QC, Chemistry/R&D, and manufacturing, and communicate progress, problems, and risks promptly.
• Share know-how with Chemists and Sr. Chemists on established procedures.

Continuous Learning and Technical Innovation

• Evaluate scientific literature, emerging oligonucleotide chemistries, and new technologies to identify opportunities for process and analytical improvements.

Minimum Qualifications

• Bachelor's or Master's degree in Chemistry, Organic Chemistry, Medicinal Chemistry, Biochemistry, Chemical Biology, or a related discipline, with relevant oligonucleotide experience (typically a BS with 5+ years or an MS with 3+ years). Ph.D. holders typically enter the ladder at the Sr. Scientist level.
• Hands-on experience in oligonucleotide synthesis, solid-phase synthesis, and phosphoramidite chemistry.
• Experience in oligonucleotide purification method development and analytical characterization.
• Proficiency in analytical and purification techniques, including HPLC/UPLC, ÄKTA chromatography systems, and LC-MS.
• Strong troubleshooting, analytical, and problem-solving skills.
• Excellent written and verbal communication skills, with the ability to work independently and collaboratively in a cross-functional team.
• Ability to work on-site in a laboratory in Union City, California.

Preferred Qualifications

• Experience with oligonucleotide bioconjugation and conjugation to other molecular modalities.
• Experience with phosphorodiamidate morpholino oligomers (PMOs).
• Experience in analytical method development.
• Background in oligonucleotide therapeutics, RNA-based therapeutics, or nucleic acid drug discovery.
• Experience in oligonucleotide process scale-up and material production.

Hongene Biotech Corporation is an Equal Opportunity Employer.