Oligonucleotide Process Development Engineer

Synthego; Redwood City (CA); On-site; USD 105,000 - 115,000; Full time

Benefits offered by this job

Medical, dental, and vision benefits

401k Program

Catered meals on Tuesday and Thursday

Paid parental leave

Flexible paid time off

Education Reimbursement Program

Job summary

Synthego is seeking a Process Development Engineer to advance the synthesis and purification of RNA and DNA oligonucleotides from nanomole to millimole scales. You will scale manufacturing processes, improve cost and quality, and transfer technology to manufacturing lines.

Collaborate with hardware, software, operations, quality, and product teams. BS in Chemistry or related field with 2–5 years in a research/manufacturing setting is preferred.

Qualifications

• BS in Chemistry or related field.
• 2-5 years of relevant industry experience in a research/manufacturing setting.
• Direct experience in synthesis and analysis of oligonucleotide products.
• Experience with Python/SQL data analysis.
• Understanding of aseptic handling techniques and liquid handling.
• Experience with large-scale instrumentation (HPLCs, synthesizers, TFF, liquid handlers).
• Strong ability to work in a fast-paced startup environment and communicate across teams.

Responsibilities

• Design, develop, and implement methods to scale oligonucleotide synthesis and purification.
• Synthesize and analyze oligonucleotides to specifications using proprietary and commercial instrumentation.
• Analyze data from UV, chromatograms, and mass spectrometry to optimize conditions and identify root causes.
• Collaborate with chemists, engineers, and scientists to execute development processes and DOE.
• Conduct experiments using automated instruments and liquid handlers.
• Write development protocols/reports and present findings to stakeholders.

Skills

Python/SQL data analysis

Strong communication

Independent/Collaborative

Education

BS in Chemistry or related field

Tools

HPLCs

Oligonucleotide/peptide synthesizers

Tangential flow filtration

Liquid handling systems

Job description

Synthego is seeking a Process Development Engineer to advance the synthesis and purification of RNA and DNA oligonucleotides from nanomole to millimole scales. You will scale manufacturing processes, improve cost and quality, and transfer technology to manufacturing lines.

Collaborate with hardware, software, operations, quality, and product teams. BS in Chemistry or related field with 2–5 years in a research/manufacturing setting is preferred.