Senior Scientist, Oligonucleotide Chemistry & Development

BioSpace; Boulder (CO); On-site; USD 70,000 - 105,000; Full time

Benefits offered by this job

Medical, dental and vision coverage

Life insurance

Disability insurance

401(k) savings plan

Flexible spending accounts

Employee assistance program

Tuition reimbursement program

Voluntary benefits

Job summary

Novo Nordisk in Boulder, CO is seeking highly motivated scientists to join its CMC Chemical Development team. You will develop scalable syntheses, work-up, purifications and isolations of oligonucleotides, and support process development and tech transfer into manufacturing.

Candidates should have a BA/BS in Chemistry, Biology, or a related field (2+ years) or a Master’s degree with relevant experience, with strong organic chemistry understanding and excellent writing and communication skills.

Qualifications

• BA/BS in Chemistry, Biology or related field with 2+ years, or Master’s degree with 0+ years of relevant industrial experience, or a High School Diploma with 10+ years relevant lab experience
• Ability to follow technical instructions of moderate complexity with independence and reduced supervision
• Responsible for experimental design/execution and analysis with limited supervision
• Demonstratable laboratory skills in synthetic organic chemistry and/or oligonucleotide synthesis, characterization and purification
• Solid understanding of synthetic organic chemistry and/or oligonucleotide relevant reactions and mechanisms
• Detail-oriented in both data analysis and project timelines
• Self-motivated with a proactive mindset
• The successful candidate must possess excellent writing and communication skills and a demonstrated ability to work independently and with cross-functional teams
• Ability to thrive in a multi-disciplinary and fast-paced research environment with tight deadlines

Responsibilities

• Provide research and development support of current chemical development projects utilizing state-of-the-art techniques for preparation and analysis of oligonucleotides or nucleic acids
• Conduct laboratory work in safe, clean, efficient manner that ensures a safe working environment for colleagues
• Characterize starting materials, intermediates and synthesized molecules using common analytical techniques such as HPLC, LCMS, NMR, GC, KF and UV-Vis
• Develop and optimize all elements of chemical transformations including reaction conditions, workup, purification and isolation. Ensure robustness and reproducibility of developed processes
• Work within Technical Operations team to develop & optimize manufacturing processes for key oligonucleotide intermediates / reagents for oligonucleotide synthesis and final API
• Document and summarize results in laboratory notebook and written reports. Capable of drawing valid conclusions from concrete and abstract variables
• Contribute to the team’s knowledge through scientific literature review and discussions
• Operate, maintain and troubleshoot common laboratory equipment
• Authoring of development and research reports to share with internal and external teams with reduced input
• Ability to complete assignments that meet clearly defined deadlines and time schedules with minimal instructions

Skills

Synthetic organic chemistry

Oligonucleotide synthesis

Independent researcher

Scientific writing

Cross-functional collaboration

Education

BA/BS in Chemistry or related field

Master’s degree in related field

High school diploma with lab experience

Tools

HPLC

LCMS

NMR

GC

KF

UV-Vis

Job description

Novo Nordisk in Boulder, CO is seeking highly motivated scientists to join its CMC Chemical Development team. You will develop scalable syntheses, work-up, purifications and isolations of oligonucleotides, and support process development and tech transfer into manufacturing.

Candidates should have a BA/BS in Chemistry, Biology, or a related field (2+ years) or a Master’s degree with relevant experience, with strong organic chemistry understanding and excellent writing and communication skills.