Senior Biophysics Scientist - Vaccine Antigen

Sanofi Group; Waltham (MA); On-site; USD 120,000 - 170,000; Full time

Job summary

Sanofi is seeking a Senior Scientist in Biophysics in Waltham, MA. You will design and perform advanced protein biochemistry assays to characterize vaccine antigen candidates, mapping epitopes, assessing conformation, and measuring thermostability to guide antigen selection.

You’ll translate complex datasets into actionable insights and partner with design, structural biology, and immunology teams to advance candidates toward the clinic.

Qualifications

• PhD with minimum 1 year postdoc in protein production/characterization.
• Experience with analytical tools and protein purification.
• Preferred experience with negative-stain EM.

Responsibilities

• Design and execute advanced protein biochemistry experiments to characterize vaccine antigen candidates to support antigen selection and further understand the antigenic surface, conformation, and stability of our antigens
• Develop and maintain a deep understanding of multiple projects to accurately analyze, interpret, and communicate complex datasets
• Support internal site-specific projects and deliver concise, compelling scientific presentations aligned with project objectives
• Collaborate cross-functionally with design, structural biology, immunology, and antibody discovery teams to integrate structural information with biochemical and biophysical data
• Demonstrate broad technical proficiency and creative problem-solving across diverse range of experimental protocols
• Contribute to the maintenance and oversight of lab facilities and equipment to ensure a safe and efficient working environment
• Critically evaluate relevant literature to provide experimental and strategic input to senior team members, and contribute to the writing and maintenance of SOPs and other required documents

Skills

Biophysics understanding

Data interpretation

Cross-functional collaboration

Education

PhD in Biochemistry/Biophysics/Immunology or related field

Tools

HPLC

SEC-MALS

DSF

DSC

BLI

SPR

Job description

Sanofi is seeking a Senior Scientist in Biophysics in Waltham, MA. You will design and perform advanced protein biochemistry assays to characterize vaccine antigen candidates, mapping epitopes, assessing conformation, and measuring thermostability to guide antigen selection.

You’ll translate complex datasets into actionable insights and partner with design, structural biology, and immunology teams to advance candidates toward the clinic.