Senior Scientist, Biophysics

Sanofi Group; Waltham (MA); On-site; USD 120,000 - 170,000; Full time

Job summary

Sanofi is seeking a Senior Scientist in Biophysics in Waltham, MA. You will design and perform advanced protein biochemistry assays to characterize vaccine antigen candidates, mapping epitopes, assessing conformation, and measuring thermostability to guide antigen selection.

You’ll translate complex datasets into actionable insights and partner with design, structural biology, and immunology teams to advance candidates toward the clinic.

Qualifications

• PhD with minimum 1 year postdoc in protein production/characterization.
• Experience with analytical tools and protein purification.
• Preferred experience with negative-stain EM.

Responsibilities

• Design and execute advanced protein biochemistry experiments to characterize vaccine antigen candidates to support antigen selection and further understand the antigenic surface, conformation, and stability of our antigens
• Develop and maintain a deep understanding of multiple projects to accurately analyze, interpret, and communicate complex datasets
• Support internal site-specific projects and deliver concise, compelling scientific presentations aligned with project objectives
• Collaborate cross-functionally with design, structural biology, immunology, and antibody discovery teams to integrate structural information with biochemical and biophysical data
• Demonstrate broad technical proficiency and creative problem-solving across diverse range of experimental protocols
• Contribute to the maintenance and oversight of lab facilities and equipment to ensure a safe and efficient working environment
• Critically evaluate relevant literature to provide experimental and strategic input to senior team members, and contribute to the writing and maintenance of SOPs and other required documents

Skills

Biophysics understanding

Data interpretation

Cross-functional collaboration

Education

PhD in Biochemistry/Biophysics/Immunology or related field

Tools

HPLC

SEC-MALS

DSF

DSC

BLI

SPR

Job description

Job Title: Senior Scientist, Biophysics

• Location: Waltham, MA

About the Job:

As a Senior Scientist in our Biophysics team, you'll design and execute advanced protein biochemistry experiments to characterize vaccine antigen candidates — driving antigen selection through epitope mapping, conformational analysis, and thermostability measurements to support rational vaccine design.

In this role, you'll use your biophysics expertise to translate complex experimental datasets into meaningful insights that inform antigen generation and selection pipelines, partnering cross-functionally with our design, structural biology, immunogenicity, and antibody teams to advance vaccine candidates toward the clinic.

Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions

About Sanofi:

We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

Main Responsibilities:

• Design and execute advanced protein biochemistry experiments to characterize vaccine antigen candidates to support antigen selection and further understand the antigenic surface, conformation, and stability of our antigens
• Develop and maintain a deep understanding of multiple projects to accurately analyze, interpret, and communicate complex datasets
• Support internal site-specific projects and deliver concise, compelling scientific presentations aligned with project objectives
• Collaborate cross-functionally with design, structural biology, immunology, and antibody discovery teams to integrate structural information with biochemical and biophysical data
• Demonstrate broad technical proficiency and creative problem-solving across diverse range of experimental protocols
• Contribute to the maintenance and oversight of lab facilities and equipment to ensure a safe and efficient working environment
• Critically evaluate relevant literature to provide experimental and strategic input to senior team members, and contribute to the writing and maintenance of SOPs and other required documents

About You:

Education:

• PhD in Biochemistry, Biophysics, Biotechnology, Immunology, Biomedical Sciences or a related field with a minimum of 1 year of relevant postdoctoral research experience, preferably in protein production/characterization or equivalent discipline.

Experience & Technical Skills:

• Knowledge and hands-on experience with various advanced analytical tools, such as HPLC, SEC-MALS, DSF, DSC, BLI, and SPR

Preferred Qualifications:

• Experience with protein purification and structural analysis, such as negative-stain EM, would be preferred

Soft Skills:

• Strong interpersonal, communication, collaboration, and problem-solving skills
• Results-oriented, data-driven, experienced in fast moving and agile environments while maintaining a high degree of integrity

Why choose us?

• Bring the miracles of science to life alongside a supportive, future focused team.
• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
• Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs.
• Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science.
• Help improve the lives of millions of people globally by making drug development quicker and more effective.

Sanofi US Services and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.