Protein ML Lead Scientist — Immunogenicity & Vaccine Design

Sanofi Group; Waltham (MA); On-site; USD 150,000 - 210,000; Full time

Benefits offered by this job

Health benefits

Parental leave

Career growth

International mobility

Job summary

Sanofi in the United States (Waltham, MA) seeks a Protein ML Senior Principal Data Scientist to design and deploy ML models predicting protein properties for next-generation vaccines. You will work at the interface of computational and lab teams to translate insights into vaccine candidates.

Ideal candidate has a PhD in a related field and 2+ years of experience, with deep Python, R, SQL, PyTorch, and experience with AlphaFold/OpenFold. Strong communication and mentoring skills are essential.

Qualifications

• PhD in Computational Biology, Data Science, Applied Mathematics, Biophysics or closely related field.
• 2+ years of industry or academic experience.

Responsibilities

• Develop state-of-the-art protein property prediction models focusing on immunogenicity, stability, and manufacturability.
• Refine language-based protein representations to accelerate vaccine candidate identification.
• Analyze relationships between protein sequences, structures and functional data to derive generalizable representations.
• Collaborate with structural biology and lab teams to shape modeling strategy and improve model quality.
• Maintain modeling codebase with robust, reproducible results and documentation.
• Mentor colleagues on protein modeling tools and techniques.
• Communicate findings clearly to diverse stakeholders including senior leadership.

Skills

Protein language models

Python

R

SQL

PyTorch

AlphaFold

ESM representations

Education

PhD in Computational Biology or related field

Tools

AlphaFold

OpenFold

Boltz

Job description

Sanofi in the United States (Waltham, MA) seeks a Protein ML Senior Principal Data Scientist to design and deploy ML models predicting protein properties for next-generation vaccines. You will work at the interface of computational and lab teams to translate insights into vaccine candidates.

Ideal candidate has a PhD in a related field and 2+ years of experience, with deep Python, R, SQL, PyTorch, and experience with AlphaFold/OpenFold. Strong communication and mentoring skills are essential.