Senior Scientist, Biophysics

Sanofi Group; United States; On-site; USD 101,000 - 145,000; Full time

Benefits offered by this job

High-quality healthcare

14 weeks gender-neutral parental leave

Prevention and wellness programs

Well-structured rewards package

Job summary

Sanofi Group in Waltham, MA, seeks a Senior Scientist in Biophysics to design and execute advanced protein biochemistry experiments that characterize vaccine antigen candidates. You will map epitopes, analyze conformations, and assess thermostability to guide antigen selection, working closely with design, structure, immunology, and antibody teams.

You should hold a PhD in Biochemistry/Biophysics or related field with postdoctoral experience, and possess hands-on expertise with HPLC, SEC-MALS,

Qualifications

• PhD with at least 1 year of relevant postdoctoral experience in protein production/characterization or related field.
• Hands-on experience with analytical tools: HPLC, SEC-MALS, DSF, DSC, BLI, SPR.
• Experience with protein purification and structural analysis (negative-stain EM) preferred.
• Strong collaboration, communication, and data interpretation skills.

Responsibilities

• Design and execute advanced protein biochemistry experiments to characterize vaccine antigen candidates.
• Analyze complex datasets and communicate insights to cross-functional teams.
• Support site-specific projects and present findings clearly to stakeholders.
• Collaborate with design, structural biology, immunology, and antibody discovery teams.
• Maintain lab facilities and contribute to SOPs and documentation.
• Evaluate literature and provide input to senior team members.

Skills

Biophysics

Protein biochemistry

Data interpretation

Education

PhD in Biochemistry/Biophysics/ Biotechnology/ Immunology/ Biomedical Sciences or related

Tools

HPLC

SEC-MALS

DSF

DSC

BLI

SPR

Negative-stain EM

Job description

Job Title & Location

Senior Scientist, Biophysics – Waltham, MA

About the Job

As a Senior Scientist in our Biophysics team, you'll design and execute advanced protein biochemistry experiments to characterize vaccine antigen candidates – driving antigen selection through epitope mapping, conformational analysis, and thermostability measurements to support rational vaccine design. In this role, you'll use your biophysics expertise to translate complex experimental datasets into meaningful insights that inform antigen generation and selection pipelines, partnering cross‑functionally with our design, structural biology, immunogenicity, and antibody teams to advance vaccine candidates toward the clinic. Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI‑powered research. In R&D, you'll drive breakthroughs that could turn the impossible into possible for millions.

About Sanofi

We’re an R&D-driven, AI‑powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

Main Responsibilities

• Design and execute advanced protein biochemistry experiments to characterize vaccine antigen candidates to support antigen selection and further understand the antigenic surface, conformation, and stability of our antigens
• Develop and maintain a deep understanding of multiple projects to accurately analyze, interpret, and communicate complex datasets
• Support internal site‑specific projects and deliver concise, compelling scientific presentations aligned with project objectives
• Collaborate cross‑functionally with design, structural biology, immunology, and antibody discovery teams to integrate structural information with biochemical and biophysical data
• Demonstrate broad technical proficiency and creative problem‑solving across diverse range of experimental protocols
• Contribute to the maintenance and oversight of lab facilities and equipment to ensure a safe and efficient working environment
• Critically evaluate relevant literature to provide experimental and strategic input to senior team members, and contribute to the writing and maintenance of SOPs and other required documents

Education

PhD in Biochemistry, Biophysics, Biotechnology, Immunology, Biomedical Sciences or a related field with a minimum of 1 year of relevant postdoctoral research experience, preferably in protein production/characterization or equivalent discipline.

Experience & Technical Skills

Knowledge and hands‑on experience with various advanced analytical tools, such as HPLC, SEC‑MALS, DSF, DSC, BLI, and SPR

Preferred Qualifications

Experience with protein purification and structural analysis, such as negative‑stain EM, would be preferred

Soft Skills

Strong interpersonal, communication, collaboration, and problem‑solving skills. Results‑oriented, data‑driven, experienced in fast moving and agile environments while maintaining a high degree of integrity

Why choose us?

Bring the miracles of science to life alongside a supportive, future focused team. Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally. Enjoy a thoughtful, well‑crafted rewards package that recognises your contribution and amplifies your impact.

• high‑quality healthcare
• prevention and wellness programs
• at least 14 weeks’ gender‑neutral parental leave

Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high‑quality healthcare, prevention and wellness programs and at least 14 weeks’ gender‑neutral parental leave. Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real‑world needs. Work at the forefront of drug discovery, harnessing cutting‑edge AI, data, and digital platforms to push the boundaries of science. Help improve the lives of millions of people globally by making drug development quicker and more effective.

Sanofi US Services and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

US and Puerto Rico Residents Only

Sanofi Inc. and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

Salary

The salary range for this position is: $100.500,00 - $145.166,66. All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.