Senior Biologics Optimization Scientist

Johnson & Johnson Innovation

Spring House (PA)

On-site

USD 170,000 - 240,000

Full time

14 days+
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Job summary

Johnson & Johnson Innovation is seeking a Principal Scientist, Biologics Optimization in Spring House, PA to lead automation-enabled discovery workflows. You will advance yeast display, NGS, and high-throughput strategies while coordinating with automation and computational teams to turn data into actionable knowledge.

Expect travel to Cambridge, MA for alignment on tech and priorities. The role emphasizes leadership, antibody engineering, developability assessment, and implementing scalable

Qualifications

  • MS degree in molecular biology, biochemistry, biotechnology or related field is required; PhD preferred.
  • 3+ years in biologics discovery, protein engineering, automation or optimization.
  • Strong leadership, collaboration and data-driven problem solving.

Responsibilities

  • Provide leadership for automation-enabled discovery workflows and throughput improvements.
  • Collaborate with automation teams to evolve yeast display, NGS and related tech.
  • Partner with cross-functional teams to guide data-driven optimization decisions.
  • Apply AI/ML and computational analyses to accelerate decisions and design principles.
  • Present findings and contribute to patents, manuscripts, and technical reports.

Skills

Biologics optimization
Antibody engineering
Automation integration
Data-driven analysis
Python programming
AI/ML collaboration
Scientific leadership
Communication
Project leadership

Education

MS in Molecular Biology or related field
PhD preferred

Tools

Schrödinger
MOE
PyMOL
Chimera
AlphaFold workflows

Job description

Johnson & Johnson Innovation is seeking a Principal Scientist, Biologics Optimization in Spring House, PA to lead automation-enabled discovery workflows. You will advance yeast display, NGS, and high-throughput strategies while coordinating with automation and computational teams to turn data into actionable knowledge.

Expect travel to Cambridge, MA for alignment on tech and priorities. The role emphasizes leadership, antibody engineering, developability assessment, and implementing scalable

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