Senior Analytical Scientist, mRNA & LNP Development

Signify Bio

Dallas (TX)

On-site

USD 85,000 - 125,000

Full time

6 days ago

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Job summary

Signify Bio seeks a hands-on Senior Research Associate for the Analytical Development team within CMC. The role focuses on routine and advanced analytical testing to support characterization, release, stability evaluations for mRNA payloads and LNP delivery systems.

You will perform biophysical and chromatographic assays, maintain instrumentation, and document data to accelerate programs. The position requires strong organizational skills, collaboration across teams, and clear written and oral

Qualifications

Bachelor’s or Master’s degree in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related field with 5–7 years of lab experience, or MS with 2–5 years.
Experience with chromatographic methods (HPLC/UPLC) and detectors (CAD/ELSD/UV); practical LNP/RNA characterization experience.

Responsibilities

Execute routine and advanced analytical testing for mRNA drug substance and LNP formulations.
Prepare reagents and standards; set up and maintain HPLC/UPLC systems and detection equipment.
Document procedures, data, and observations in ELN following SOPs.
Collaborate with Formulation Process Development and Molecular Biology teams to support screening and process optimization.
Assist in method drafting, protocol execution, and sample tracking for stability studies.
Present findings at team meetings and contribute to technical discussions.