Senior LNP Formulation & Process Development Scientist

Signify Bio; Dallas (TX); On-site; USD 70,000 - 110,000; Full time

Job summary

Signify Bio seeks a proactive Senior Research Associate for the Formulation and Process Development team. You will handle full-spectrum formulation manufacturing from screening to scalable batches, supporting lipid nanoparticle formulations encapsulating mRNA payloads.

Work closely with process development and analytical teams to optimize CPPs, perform downstream purification, and document experiments in ELN for early-stage research through candidate nomination.

Qualifications

• MS or BS with relevant hands-on lab experience in lipid nanoparticle formulation or drug delivery.
• Experience formulating LNPs or liposomes for screening or process development.
• Proficiency with particle characterization and nucleic acid quantification techniques.

Responsibilities

• Execute rapid screening-scale LNP preparations from sub-mL to low-mL volumes.
• Prepare LNP formulations across research and process development scales.
• Prepare lipid and aqueous phases according to targeted molar ratios.
• Transition research leads into scalable process development batches.
• Evaluate CPPs including flow rates, mixing shear, and diafiltration volumes.
• Perform downstream purification and buffer exchange of LNP formulations.
• Conduct in-process analytics (DLS, zeta potential, RiboGreen).
• Draft SOPs and document batch records in ELN.

Skills

LNP formulation

Microfluidics

TFF/UF-DF systems

DLS (particle size)

RiboGreen assay

NTA

Analytical data tracking

Documentation in ELN

Education

MS in Chemical/Biomedical/Biochemical Engineering or related with 3-5 years lab experience

BS with 5-7 years drug delivery/LNP formulation experience

Tools

Tangential Flow Filtration

Impending jet mixing

Crossflow impinging jet mixing

Hollow-fiber systems

Job description

Signify Bio seeks a proactive Senior Research Associate for the Formulation and Process Development team. You will handle full-spectrum formulation manufacturing from screening to scalable batches, supporting lipid nanoparticle formulations encapsulating mRNA payloads.

Work closely with process development and analytical teams to optimize CPPs, perform downstream purification, and document experiments in ELN for early-stage research through candidate nomination.