Senior Research Associate, Analytical Development

Signify Bio; Dallas (TX); On-site; USD 85,000 - 125,000; Full time

Job summary

Signify Bio seeks a hands-on Senior Research Associate for the Analytical Development team within CMC. The role focuses on routine and advanced analytical testing to support characterization, release, stability evaluations for mRNA payloads and LNP delivery systems.

You will perform biophysical and chromatographic assays, maintain instrumentation, and document data to accelerate programs. The position requires strong organizational skills, collaboration across teams, and clear written and oral

Qualifications

• Bachelor’s or Master’s degree in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related field with 5–7 years of lab experience, or MS with 2–5 years.
• Experience with chromatographic methods (HPLC/UPLC) and detectors (CAD/ELSD/UV); practical LNP/RNA characterization experience.

Responsibilities

• Execute routine and advanced analytical testing for mRNA drug substance and LNP formulations.
• Prepare reagents and standards; set up and maintain HPLC/UPLC systems and detection equipment.
• Document procedures, data, and observations in ELN following SOPs.
• Collaborate with Formulation Process Development and Molecular Biology teams to support screening and process optimization.
• Assist in method drafting, protocol execution, and sample tracking for stability studies.
• Present findings at team meetings and contribute to technical discussions.

Skills

Chromatography methods (HPLC/UPLC)

CAD/ELSD/UV detectors

RNA/LNP characterization tools (DLS, R

Team collaboration

Troubleshooting

Written and oral communication

Education

Bachelor’s or Master’s in Analytical Chemistry / related field

Tools

HPLC/UPLC

DLS (Zetasizer)

RiboGreen encapsulation

Capillary electrophoresis

Job description

Signify Bio is a biotechnology company transforming the development of in situ protein therapeutics by leveraging the human body's natural ability to produce proteins. Guided by its mission to create personalized medicines for all, Signify combines the precision of signal peptide engineered control with the speed and versatility of mRNA encoded design. The company's SEND platform and iPhos lipid nanoparticles enable targeted and localized delivery of therapeutic proteins, addressing significant unmet needs across various diseases. Through innovative science, Signify Bio is committed to advancing solutions that make a meaningful difference for patients worldwide.

At Signify, we bring together collaborative teams, innovative science, and a shared commitment to addressing meaningful unmet patient needs. Employees have the opportunity to work across disciplines, contribute to cutting-edge therapeutic programs, and help translate scientific discoveries into potential medicines. We value scientific rigor, open communication, curiosity, and teamwork, and we encourage every team member to contribute ideas, take ownership, and grow alongside the organization.

Position Summary

We seek a hands-on, detail-oriented Senior Research Associate to join our Analytical Development team within the CMC organization. In this newly-created role, the Senior RA will perform routine and advanced analytical testing to support characterization, release, and stability evaluations for Signify's mRNA payloads (SEND platform) and LNP delivery systems (iPHOS platform). This role also focuses on executing biophysical and chromatographic assays, maintaining laboratory instrumentation, and documenting data to accelerate our internal and partnered therapeutic programs.

• Execute routine and non-routine analytical assays for mRNA drug substance and LNP formulation characterization, including HPLC/UPLC (RP, SEC, IEX with CAD/UV), capillary electrophoresis, dynamic light scattering (DLS), particle sizing, and dye-binding (RiboGreen/encapsulation) assays.
• Prepare reagents, analytical standards, and mobile phases; perform instrument setup, routine maintenance, and troubleshooting for HPLC/UPLC systems and biophysical detection equipment.
• Document experimental procedures, raw data, and scientific observations meticulously in Electronic Lab Notebooks (ELN) following established SOPs.
• Collaborate closely with Formulation Process Development and Molecular Biology teams to analyze samples in a timely manner to support screening and process optimization.
• Assist in method drafting, protocol execution, assay qualification, and sample tracking for stability studies.
• Present experimental findings clearly at internal team meetings and contribute to technical discussions.

Qualifications - Education

B.S. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related discipline with 5-7 years of relevant industry or academic laboratory experience; or M.S. with 2-5 years of related experience.

Qualifications - Work Experience & Skills

• Hands-on experience with chromatographic methods (HPLC/UPLC) for small molecules, lipids, or nucleic acids; experience with CAD, ELSD, or UV detectors is preferred.
• Practical experience in LNP or RNA characterization tools (e.g., DLS/Zetasizer, RiboGreen encapsulation, capillary gel electrophoresis) is highly desirable.
• Strong organizational skills with high attention to detail in data collection and record-keeping.
• Proven ability to work collaboratively and execute multi-step analytical protocols reliably.
• Strong troubleshooting abilities regarding standard analytical instrumentation and experimental workflows.
• Clear written and oral communication skills.

Physical Requirements

Position requires the physical ability to work in a lab setting and utilize standard lab equipment for extended periods of time. Occasional travel (<10%>) may be required, typically domestic.

Signify Bio is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law.