Lead, mRNA & LNP Analytical Development

Signify Bio; Dallas (TX); On-site; USD 180,000 - 240,000; Full time

Job summary

Signify Bio is seeking a Principal Scientist to lead the mRNA and Lipid Nanoparticle Analytical Development team within the CMC organization. You will develop, validate, and implement analytical assays to characterize mRNA drug substance, lipid materials, and LNP drug products for SEND mRNA and iPHOS LNP platforms.

Responsibilities include establishing control strategies, release/stability panels, and supporting regulatory filings while mentoring scientists and collaborating with Formulation,

Qualifications

• Deep expertise in analytical development for mRNA constructs and LNPs.
• Proven experience in chromatography, electrophoresis, and light scattering for LNPs.
• Strong record of mentoring lab researchers and managing projects.
• Understanding of analytical control strategies and stability testing for nucleic acids and nanoparticles.

Responsibilities

• Lead analytical development for mRNA drug substance and LNP products.
• Design and qualify assays including HPLC/UPLC, capillary electrophoresis, and DLS.
• Establish panels for release, stability, and characterization of candidates.
• Mentor analytical scientists and oversee lab operations.
• Coordinate tech transfer to CDMOs/CTOs and support scale-up with CMC teams.
• Communicate complex data to leadership and project teams.

Skills

Analytical development

mRNA constructs

Lipid nanoparticle formulations

Team mentoring

Cross-functional collaboration

Communication skills

Education

PhD or equivalent in Analytical Chemistry / Pharmaceutical Sciences / Biochemistry

M.S. with 12+ years of related biopharma experience

Tools

RP-HPLC / SEC / IEX / CAD/ELSD

Capillary electrophoresis

Dynamic light scattering (DLS)

RiboGreen/encapsulation assays

Job description

Signify Bio is seeking a Principal Scientist to lead the mRNA and Lipid Nanoparticle Analytical Development team within the CMC organization. You will develop, validate, and implement analytical assays to characterize mRNA drug substance, lipid materials, and LNP drug products for SEND mRNA and iPHOS LNP platforms.

Responsibilities include establishing control strategies, release/stability panels, and supporting regulatory filings while mentoring scientists and collaborating with Formulation,