Scientist IV - Biotherapeutics; Biotherapeutics Purification

Boehringer Ingelheim; Ridgefield (CT); Presencial; USD 109 000 - 163 000; Tempo integral

Vantagens oferecidas por esta oferta de emprego

Bonus program

Relocation assistance

Medical, dental, and vision

Resumo da oferta

Boehringer Ingelheim Pharmaceuticals, Inc. in Ridgefield, CT seeks an innovative Scientist IV, Biotherapeutics Purification to advance purification and analytics for therapeutic proteins.

You will design and execute purification workflows, analyze production data, and liaise with Biotherapeutics Discovery teams to drive quality and insight. A strong background in chromatography and analytical methods, plus independent initiative, is required.

Qualificações

• Master's degree with 6+ years in related field or Bachelor's with 10+ years.
• Extensive experience with protein purification (affinity, AEX/CEX, MMC, HIC).
• Experience with protein analytics (SDS-PAGE, CGE, U/HPLC, DLS).
• Knowledge of protein expression is preferred.
• Experience with data analysis software and programming (MATLAB, Python, SQL, Java).
• Familiarity with lab automation is preferred.
• Strong grasp of protein biochemistry and stability attributes.
• Creative problem solving and ability to work independently or in teams.
• Excellent record-keeping, organization, and communication skills.

Responsabilidades

• Plan, coordinate, and perform purification of biotherapeutic proteins using chromatography.
• Analyze protein purity, stability, and quality using standard analytical methods.
• Evaluate new technologies to improve productivity, quality of purification processes.
• Perform stage-appropriate purification assessments and present findings.
• Develop analytical methodologies and evaluate new technologies for team capabilities.
• Provide protein biochemistry and purification support to Biotherapeutics Discovery scientists.

Conhecimentos

Protein purification

Protein analytics

Data analysis software

Programming languages

Lab automation

Protein biochemistry

Problem solving

Attention to detail

Communication skills

Experiment design

Formação académica

Master's degree + 6+ years experience

Bachelor's degree + 10+ years experience

Ferramentas

MATLAB

Mathematica

Python

SQL

Java

JMP

R

Minitab

Statistica

Descrição da oferta de emprego

Scientist IV - Biotherapeutics; Biotherapeutics Purification

Description

Boehringer Ingelheim is currently seeking an innovative and ambitious Scientist IV, Biotherapeutics Purification to join our Biotherapeutics Discovery department located at our Ridgefield, CT facility.

We are seeking a talented and experienced Scientist IV who will conduct protein purification and analytics to support development of protein biotherapeutics in a fast-paced research environment. This person will be primarily responsible for designing and executing protein purification and analytics as well as, analyzing and interpreting assays and production data to understand inherent protein attributes and physicochemical stability.

The ideal candidate will be an analytical thinker with creative problem-solving skills; a quick learner who takes the initiative and manages workflows for several projects with enthusiasm and resourcefulness; an effective collaborator, working with different functional areas to enhance project knowledge.

As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunities for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.

Duties & Responsibilities

• Plan, coordinate and perform purification of biotherapeutic proteins using standard chromatography methods (Affinity capture, SEC, CEX, AEX, MMC, HIC). Troubleshoot complex systems as necessary through process development.
• Perform standard analytical techniques to assess protein purity, stability and quality (HPLC-SEC, SDS-PAGE, CGE, DLS)
• Evaluate new technologies and process changes to improve the productivity, quality, and consistency of standard platform processes.
• Perform stage appropriate purification assessments, including screening of protein behaviors and attributes in relevant process conditions, interpret and present findings to other Biotherapeutics Discovery colleagues.
• Develop novel analytical methodologies and evaluate new technologies to improve purification team capabilities
• Contribute to broader research goals in areas related to protein biochemistry aimed at developing a better understanding of therapeutic protein structure, stability, dynamics, and function.
• Provide protein biochemistry and protein purification support for other scientists across Biotherapeutics Discovery; perform other tasks assigned by manager in a timely manner.
• Improve data quality, consistency, and throughput using automation and analysis scripts. Identify opportunities for innovative automation strategies to streamline operations and boost workflow efficiency.
• Comply with all applicable regulations, perform all work in a safe manner; maintain proper records in accordance with SOP’s and policies.

Requirements

• Master’s Degree from an accredited institution with six-plus (6+) years of experience in related scientific discipline, OR Bachelor’s Degree from an accredited institution with ten-plus (10+) years of experience in related scientific discipline or equivalent experience in related field
• Considerable experience with protein purification techniques such as affinity chromatography, ion exchange chromatography (AEX,CEX), Mixed mode chromatography (MMC), and/or Hydrophobic interaction chromatography (HIC)
• Experience conducting standard protein analytics to assess quality and stability (SDS-PAGE, CGE, U/HPLC, DLS)
• Knowledge and experience with protein expression preferred.
• Experience with data analysis software and/or modern computer programming languages (MATLAB, Mathematica, Python, SQL, or Java); experience in statistical and DOE software (JMP, R, Minitab, Statistica) is beneficial.
• Familiarity with lab automation is preferred.
• Strong grasp of protein biochemistry principles underpinning protein interactions, stability, and biotherapeutic quality attributes.
• Creative problem solving with a high level of initiative and ability to work independently as well as collaboratively
• Good record-keeping and organizational skills with exceptional attention to detail.
• Excellent writing, presenting, and communicating skills.

Eligibility Requirements:

• Must be legally authorized to work in the United States without restriction.
• Must be willing to take a drug test and post-offer physical (if required).
• Must be 18 years of age or older.

Compensation Data

The base salary range for this position is $108,800 to $163,200. The position may be eligible for a role-specific discretionary bonus, relocation assistance, and/or other compensation elements. We continuously review market data and may adjust salary ranges as needed in the future. Actual compensation will be based on job-related factors such as skills, experience, qualifications, and other factors permitted by law. Benefits include medical, dental, and vision coverage, retirement savings opportunities, paid time off, paid holidays, disability and life insurance benefits, and other company-sponsored benefits. For additional information regarding our benefits and Total Rewards offerings, please click here .