Scientist IV - Biotherapeutics; Biotherapeutics Purification

Boehringer Ingelheim; Ridgefield (CT); On-site; USD 109,000 - 163,000; Full time

Benefits offered by this job

Health insurance

Dental coverage

Vision coverage

Retirement savings plan

Paid time off

Relocation assistance

Job summary

Boehringer Ingelheim is seeking an innovative Scientist IV, Biotherapeutics Purification in Ridgefield, CT to lead purification and analytics for protein biotherapeutics in a fast-paced research environment.

The role focuses on designing and executing purification methods, analyzing assays and production data, and collaborating across functional areas to advance projects. Strong problem-solving, communication and automation skills are required in a dynamic team setting.

Qualifications

• Master’s degree with 6+ years or Bachelor’s with 10+ years in related field
• Experience with purification techniques: affinity, AEX/CEX, MMC, HIC
• Experience with protein analytics: SDS-PAGE, CGE, U/HPLC, DLS
• Knowledge of protein expression preferred
• Proficiency in data analysis software and programming (MATLAB, Mathematica, Python, SQL, Java)
• Familiarity with lab automation
• Strong protein biochemistry knowledge on interactions, stability, quality attributes
• Creative problem solving and initiative; ability to work independently and in teams
• Good record-keeping, organization, and communication skills
• Eligibility to work in the United States without restriction

Responsibilities

• Plan, coordinate and perform purification of biotherapeutic proteins using standard chromatography methods
• Troubleshoot complex systems through process development
• Perform analytics to assess purity, stability and quality (HPLC-SEC, SDS-PAGE, CGE, DLS)
• Evaluate new technologies to improve productivity and quality
• Conduct stage-appropriate purification assessments and present findings
• Develop novel analytical methodologies to enhance purification capabilities
• Support broader biotherapeutics discovery research on protein structure and stability
• Provide purification support to other scientists and maintain records per SOPs and policies

Skills

Analytical thinking

Creative problem solving

Independent work

Team collaboration

Data analysis

Programming (MATLAB)

Programming (Python)

Programming (SQL)

Programming (Java)

Education

Master’s Degree in related field

Bachelor’s Degree in related field + 10+ years experience

Tools

Affinity chromatography

Ion exchange chromatography (AEX/CEX)

Mixed mode chromatography (MMC)

Hydrophobic interaction chromatography (HIC)

HPLC-SEC

SDS-PAGE

CGE

U/HPLC

DLS

SDS-PAGE

MATLAB

Mathematica

Python

SQL

Java

Job description

Boehringer Ingelheim is currently seeking an innovative and ambitious Scientist IV, Biotherapeutics Purification to join our Biotherapeutics Discovery department located at our Ridgefield, CT facility.

We are seeking a talented and experienced Scientist IV who will conduct protein purification and analytics to support development of protein biotherapeutics in a fast-paced research environment. This person will be primarily responsible for designing and executing protein purification and analytics as well as, analyzing and interpreting assays and production data to understand inherent protein attributes and physicochemical stability.

The ideal candidate will be an analytical thinker with creative problem-solving skills; a quick learner who takes the initiative and manages workflows for several projects with enthusiasm and resourcefulness; an effective collaborator, working with different functional areas to enhance project knowledge.

As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunities for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.

Duties & Responsibilities

• Plan, coordinate and perform purification of biotherapeutic proteins using standard chromatography methods (Affinity capture, SEC, CEX, AEX, MMC, HIC). Troubleshoot complex systems as necessary through process development.
• Perform standard analytical techniques to assess protein purity, stability and quality (HPLC-SEC, SDS-PAGE, CGE, DLS)
• Evaluate new technologies and process changes to improve the productivity, quality and consistency of standard platform processes.
• Perform stage appropriate purification assessments, including screening of protein behaviors and attributes in relevant process conditions, interpret and present findings to other Biotherapeutics Discovery colleagues.
• Develop novel analytical methodologies and evaluate new technologies to improve purification team capabilities
• Contribute to broader research goals in areas related to protein biochemistry aimed at developing a better understanding of therapeutic protein structure, stability, dynamics, and function.
• Provide protein biochemistry and protein purification support for other scientists across Biotherapeutics Discovery; perform other tasks assigned by manager in a timely manner.
• Improve data quality, consistency, and throughput using automation and analysis scripts. Identify opportunities for innovative automation strategies to streamline operations and boost workflow efficiency.
• Comply with all applicable regulations, perform all work in a safe manner; maintain proper records in accordance with SOP’s and policies.

Requirements

• Master’s Degree from an accredited institution with six-plus (6+) years of experience in related scientific discipline, OR Bachelor’s Degree from an accredited institution with ten-plus (10+) years of experience in related scientific discipline or equivalent experience in related field
• Considerable experience with protein purification techniques such as affinity chromatography, ion exchange chromatography (AEX,CEX), Mixed mode chromatography (MMC), and/or Hydrophobic interaction chromatography (HIC)
• Experience conducting standard protein analytics to assess quality and stability (SDS-PAGE, CGE, U/HPLC, DLS)
• Knowledge and experience with protein expression preferred.
• Experience with data analysis software and/or modern computer programming languages (MATLAB, Mathematica, Python, SQL, or Java); experience in statistical and DOE software (JMP, R, Minitab, Statistica) is beneficial.
• Familiarity with lab automation is preferred.
• Strong grasp of protein biochemistry principles underpinning protein interactions, stability, and biotherapeutic quality attributes.
• Creative problem solving with a high level of initiative and ability to work independently as well as collaboratively
• Good record-keeping and organizational skills with exceptional attention to detail.
• Excellent writing, presenting, and communicating skills.

Eligibility Requirements

• Must be legally authorized to work in the United States without restriction.
• Must be willing to take a drug test and post-offer physical (if required).
• Must be 18 years of age or older.

Compensation Data

The base salary range for this position is $108,800 to $163,200. The position may be eligible for a role-specific discretionary bonus, relocation assistance, and/or other compensation elements. We continuously review market data and may adjust salary ranges as needed in the future. Actual compensation will be based on job-related factors such as skills, experience, qualifications, and other factors permitted by law. Benefits include medical, dental, and vision coverage, retirement savings opportunities, paid time off, paid holidays, disability and life insurance benefits, and other company-sponsored benefits.

Our Company

Boehringer Ingelheim is a biopharmaceutical company active in both human and animal health. As one of the industry's top investors in research and development, the company focuses on developing innovative therapies that can improve and extend lives in areas of high unmet medical need. Independent since its foundation in 1885, Boehringer takes a long-term perspective, embedding sustainability along the entire value chain. Our approximately 54,300 employees serve over 130 markets to build a healthier and more sustainable tomorrow. Learn more at www.boehringer-ingelheim.com.

Why Boehringer Ingelheim?

With us, you can develop your own path in a company with a culture that knows our differences are our strengths - and break new ground in the drive to make millions of lives better.

Here, your development is our priority. Supporting you to build a career as part of a workplace that is independent, authentic and bold, while tackling challenging work in a respectful and friendly environment where everyone is valued and welcomed.

Alongside, you have access to programs and groups that ensure your health and wellbeing are looked after - as we make major investments to drive global accessibility to healthcare. By being part of a team that is constantly innovating, you'll be helping to transform lives for generations.

Want to learn more? Visit https://www.boehringer-ingelheim.com