Scientist IV - Biotherapeutics; Biotherapeutics Purification

BioCT Innovation Commons; Ridgefield (CT); Presencial; USD 109 000 - 163 000; Tempo integral

Resumo da oferta

Boehringer Ingelheim’s Biotherapeutics Discovery team in Ridgefield, CT seeks an innovative Scientist IV, Biotherapeutics Purification to design and execute protein purification and analytics supporting the development of biotherapeutics.

The role spans purification using affinity, SEC, AEX/CEX, MMC, and HIC, analytical assessments (SDS-PAGE, CGE, HPLC-SEC, DLS), data interpretation, and automation initiatives, with collaboration across teams and strict regulatory documentation.

Qualificações

• Master's degree with 6+ years of experience or Bachelor's degree with 10+ years in related field.
• Experience with protein purification techniques (affinity, AEX/CEX, MMC, HIC).
• Experience with protein analytics (SDS-PAGE, CGE, U/HPLC, DLS).
• Proficiency in data analysis software and programming languages (MATLAB, Python, SQL; JMP/R is beneficial).
• Familiarity with lab automation preferred.

Responsabilidades

• Plan and perform purification of biotherapeutic proteins using chromatography methods and troubleshoot.
• Perform analytical techniques to assess purity, stability, and quality of proteins.
• Evaluate new technologies to improve productivity and consistency of processes.
• Conduct purification assessments and interpret findings for colleagues.
• Develop new analytical methodologies and automation to boost throughput.
• Provide biochemistry and purification support to other scientists.
• Improve data quality and implement automation to streamline workflows.
• Maintain records according to SOPs and policies.

Conhecimentos

Protein purification

Protein analytics

Data analysis software

Lab automation

Programming languages

Formação académica

Master's degree

Bachelor's degree

Ferramentas

MATLAB

Python

SQL

Descrição da oferta de emprego

Description

Boehringer Ingelheim is currently seeking an innovative and ambitious Scientist IV, Biotherapeutics Purification to join our Biotherapeutics Discovery department located at our Ridgefield, CT facility.

We are seeking a talented and experienced Scientist IV who will conduct protein purification and analytics to support development of protein biotherapeutics in a fast-paced research environment. This person will be primarily responsible for designing and executing protein purification and analytics as well as, analyzing and interpreting assays and production data to understand inherent protein attributes and physicochemical stability.

The ideal candidate will be an analytical thinker with creative problem-solving skills; a quick learner who takes the initiative and manages workflows for several projects with enthusiasm and resourcefulness; an effective collaborator, working with different functional areas to enhance project knowledge.

As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunities for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.

Duties & Responsibilities

• Plan, coordinate and perform purification of biotherapeutic proteins using standard chromatography methods (Affinity capture, SEC, CEX, AEX, MMC, HIC). Troubleshoot complex systems as necessary through process development.
• Perform standard analytical techniques to assess protein purity, stability and quality (HPLC-SEC, SDS-PAGE, CGE, DLS)
• Evaluate new technologies and process changes to improve the productivity, quality, and consistency of standard platform processes.
• Perform stage appropriate purification assessments, including screening of protein behaviors and attributes in relevant process conditions, interpret and present findings to other Biotherapeutics Discovery colleagues.
• Develop novel analytical methodologies and evaluate new technologies to improve purification team capabilities
• Contribute to broader research goals in areas related to protein biochemistry aimed at developing a better understanding of therapeutic protein structure, stability, dynamics, and function.
• Provide protein biochemistry and protein purification support for other scientists across Biotherapeutics Discovery; perform other tasks assigned by manager in a timely manner.
• Improve data quality, consistency, and throughput using automation and analysis scripts. Identify opportunities for innovative automation strategies to streamline operations and boost workflow efficiency.
• Comply with all applicable regulations, perform all work in a safe manner; maintain proper records in accordance with SOP’s and policies.

Requirements

• Master’s Degree from an accredited institution with six-plus (6+) years of experience in related scientific discipline, OR Bachelor’s Degree from an accredited institution with ten-plus (10+) years of experience in related scientific discipline or equivalent experience in related field
• Considerable experience with protein purification techniques such as affinity chromatography, ion exchange chromatography (AEX,CEX), Mixed mode chromatography (MMC), and/or Hydrophobic interaction chromatography (HIC)
• Experience conducting standard protein analytics to assess quality and stability (SDS-PAGE, CGE, U/HPLC, DLS)
• Knowledge and experience with protein expression preferred.
• Experience with data analysis software and/or modern computer programming languages (MATLAB, Mathematica, Python, SQL, or Java); experience in statistical and DOE software (JMP, R, Minitab, Statistica) is beneficial.
• Familiarity with lab automation is preferred.
• Strong grasp of protein biochemistry principles underpinning protein interactions, stability, and biotherapeutic quality attributes.
• Creative problem solving with a high level of initiative and ability to work independently as well as collaboratively
• Good record-keeping and organizational skills with exceptional attention to detail.
• Excellent writing, presenting, and communicating skills.

Eligibility Requirements

• Must be legally authorized to work in the United States without restriction.
• Must be willing to take a drug test and post-offer physical (if required).
• Must be 18 years of age or older.

Compensation Data

The base salary range for this position is $108,800 to $163,200. The position may be eligible for a role-specific discretionary bonus, relocation assistance, and/or other compensation elements. We continuously review market data and may adjust salary ranges as needed in the future. Actual compensation will be based on job-related factors such as skills, experience, qualifications, and other factors permitted by law. Benefits include medical, dental, and vision coverage, retirement savings opportunities, paid time off, paid holidays, disability and life insurance benefits, and other company-sponsored benefits.