Scientist – In Vivo CAR-T Therapy

American Society of Gene & Cell Therapy; Philadelphia (Philadelphia County); On-site; USD 110,000 - 140,000; Full time

Job summary

Legend Biotech USA, Inc. seeks a Scientist – In Vivo CAR-T Therapy in Philadelphia, PA to design, plan, and execute in vivo experiments advancing cell and gene therapy platforms. You will optimize assays, analyze data, and maintain rigorous documentation supporting translational efforts.

The role requires a PhD in immunology, biology, biochemistry, or related field with hands-on research experience, including in vivo CAR-T work, and strong communication skills for cross-functional collaboration.

Qualifications

• PhD in immunology or a closely related field with hands-on cell and/or gene therapy experience.
• Experience with in vivo CAR-T development and preclinical studies.
• Proficiency with ELISA, PCR, and viral vector packaging/titration.
• Strong data analysis and meticulous documentation skills.

Responsibilities

• Design and execute in vivo CAR-T studies to advance preclinical programs.
• Analyze experimental data and prepare technical reports for translation.
• Collaborate with R&D for concept translation into therapeutic candidates.
• Communicate findings through presentations to cross-functional teams.

Skills

In vivo CAR-T

Cell line engineering

Cytotoxicity assays

ELISA

PCR

Viral vector packaging

High-throughput screening

Education

PhD in Immunology/Biology/Biochemistry/Chemistry

Job description

Legend Biotech USA, Inc. seeks Scientist – In Vivo CAR-T Therapy in Philadelphia, PA. Design, plan, and execute experimental studies to advance cell and gene therapy platforms and pipeline programs, focusing on in vivo CAR-T development from early discovery through preclinical development. Conduct and analyze in vitro and in vivo studies to evaluate product potency, efficacy, and safety. Develop, optimize, validate, and troubleshoot experimental assays and laboratory methods, including cell line engineering, cell-based functional and cytotoxicity assays, ELISA and PCR-based assays, high-throughput binder screening, and viral vector packaging and titration. Analyze, interpret, and summarize scientific data and maintain experimental records and documentation. Prepare technical reports, summaries, and presentations to communicate research findings, results, and conclusions. Collaborate with research and early development teams to support translation of scientific concepts into therapeutic candidates and advancement of cell and gene therapy programs. Requires PhD in Immunology, Biology, Biochemistry, Chemistry, or a closely related field, plus 2 years of experience in hands-on cell and/or gene therapy research. $119,692/year.