Scientist, In Vivo CAR-T Therapy

Legend Biotech USA, Inc.; Philadelphia (Philadelphia County); On-site; USD 108,000 - 132,000; Full time

Job summary

Legend Biotech USA, Inc is seeking a Scientist - In Vivo CAR-T Therapy to lead design and execution of studies advancing CAR-T programs from discovery through preclinical development. The role involves both in vitro and in vivo work, assay development, data interpretation, and documentation.

The ideal candidate has a PhD in a related field and at least 2 years of hands-on cell or gene therapy experience, with strong collaboration skills in a cross-functional environment.

Qualifications

• PhD in a relevant field (Immunology/Biology/Biochemistry/Chemistry).
• 2+ years hands-on cell and/or gene therapy research experience.

Responsibilities

• Design, plan, and execute studies to advance cell and gene therapy platforms, focusing on in vivo CAR-T development.
• Conduct in vitro and in vivo studies to evaluate potency, efficacy, and safety.
• Develop and validate assays and methods including cell line engineering, cytotoxicity assays, ELISA, PCR-based assays, and viral vector work.
• Prepare clear technical reports and present findings to cross-functional teams.

Skills

Cell/gene therapy experience

Data analysis

Education

PhD in Immunology

Tools

Viral vector packaging

PCR-based assays

Job description

COMPANY

Legend Biotech USA, Inc

JOB TITLE

Scientist - In Vivo CAR-T Therapy

JOB DUTIES

The Scientist - In Vivo CAR-T Therapy will have the following duties: Design, plan, and execute experimental studies to advance cell and gene therapy platforms and pipeline programs, with a focus on in vivo CAR T development from early discovery through preclinical development. Conduct and analyze in vitro and in vivo studies to evaluate product potency, efficacy, and safety. Develop, optimize, validate, and troubleshoot experimental assays and laboratory methods, including cell line engineering, cell-based functional and cytotoxicity assays, ELISA and PCR-based assays, high-throughput binder screening, and viral vector packaging and titration. Analyze, interpret, and summarize complex scientific data generated from experimental studies and maintain accurate, complete, and well-organized experimental records and documentation. Prepare clear, detailed, and high-quality technical reports, summaries, and presentations to communicate research findings, experimental results, and scientific conclusions. Collaborate closely with internal research and early development teams in a cross-functional environment to support translation of novel scientific concepts into therapeutic candidates and advancement of cell and gene therapy research programs.

MINIMUM JOB REQUIREMENTS

Education Required: PhD in Immunology, Biology, Biochemistry, Chemistry or a closely related field. Experience Required: 2 yrs of experience in hands on experience in cell and/or gene therapy research.

JOB SITE

2300 Market St., 3rd Floor, Philadelphia, PA 19103

WORK HOURS

9:00 a.m. to 5:00 p.m. 5 days 40 hr/wk

SALARY

$119,692.00 per year

The base pay range below is what Legend Biotech USA Inc. reasonably expects to offer at the time of posting. Actual compensation may vary based on experience, skills, qualifications, and geographic location. The company reserves the right to modify this range as needed and in accordance with applicable laws.

Other Types of Pay: Performance-based bonus and/or equity is available to employees in eligible roles.

Benefits and Paid Time Off: Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays. Additional voluntary benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide voluntary commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs; demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.

Pay Range (Base Pay)

$119,692—$119,692 USD

Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.

Work Authorization & Employment Eligibility

Applicants must be authorized to work in the United States. As part of our commitment to maintaining a lawful workforce and ensuring compliance with federal employment regulations, we participate in the E-Verify program. If you are selected for employment, you will be required to complete the Form I-9 process, and your employment eligibility will be verified through E-Verify in accordance with applicable federal law. We are committed to providing a fair, transparent, and welcoming hiring experience for all candidates.

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.

For information related to our privacy notice, please review: Legend Biotech Privacy Notice.