Scientist II, Protein Science (12-Month Position)

BioSpace; Weston (MA); On-site; USD 120,000 - 170,000; Full time

Job summary

ModeX Therapeutics, an OPKO Health company, is seeking a Scientist II, Protein Science – 12 month position located in Weston, MA. You will join a multidisciplinary Protein Science group to design, produce and characterize multispecific antibodies in a fast-paced biotech setting.

The role involves collaboration with Biologics Discovery and Drug Development teams, high-throughput construct assembly, and in-depth analytical characterization using BLI/SPR, ELISA, HPLC/UPLC.

Qualifications

• MS or PhD in protein science, biochemistry, structure biology or related field.
• MS with 10+ years or PhD with 3+ years in antibody/biologics discovery and development.
• Experience with mammalian cell culture and recombinant protein expression.
• Purification using affinity, IEX, SEC and mixed mode chromatography.

Responsibilities

• Collaborate to drive design, production and screen of multispecific antibodies and optimize biochemical/biophysical properties.
• Lead feasibility assessments and PoC molecule development; perform lead identification and optimization using biochemical and cell-based assays.
• High-throughput multispecific antibody construct assembly and purification; assess potency and stability.
• Plan experiments, analyze data, and communicate with cross-functional teams for project success.
• Document all work thoroughly in electronic lab notebooks.

Skills

Protein expression

Mammalian cell culture

AKTA chromatography

Biologics

BLI/SPR

Data analysis

Education

MS or PhD in protein science/biochemistry

Tools

AKTA systems

HPLC/UPLC

ELISA

FACS

Job description

Company Overview

ModeX Therapeutics, an OPKO Health company, is the leading clinical-stage biopharmaceutical company developing unique and proprietary-multispecific therapeutics. Its MSTAR platform unites the power of multiple biologics in a single molecule to create multispecific antibodies that bind four or more targets with unprecedented versatility and potency for complex diseases. Its promising first-in-class immunology pipeline includes candidates against immune diseases, including cancer (both solid and hematologic tumors), immune impairment, as well as several of the world’s most pressing viral threats. Its founding team includes globally recognized medical innovators with proven track records of delivering breakthroughs for patients. ModeX is based in Weston, Massachusetts. For more information, please visitwww.modextx.com.

Job Description

Job Title: Scientist II, Protein Science – 12 month position

Location: Weston, MA

Reports To: Head of Protein Science

Company Overview

ModeX Therapeutics, an OPKO Health company, is the leading clinical-stage biopharmaceutical company developing unique and proprietary multispecific therapeutics. Its MSTAR platform unites the power of multiple biologics in a single molecule to create multispecific antibodies that bind four or more targets with unprecedented versatility and potency for complex diseases. Its promising first-in-class immunology pipeline includes candidates against immune diseases, including cancer (both solid and hematologic tumors), immune impairment, as well as several of the world’s most pressing viral threats. Its founding team includes globally recognized medical innovators with proven track records of delivering breakthroughs for patients. ModeX is based in Weston, Massachusetts. For more information, please visitwww.modextx.com.

Job Summary

We are seeking a highly skilled and motivated biochemist to join our Protein Science group. The individual will be part of a multidisciplinary team to design, produce and characterize novel multispecific antibodies. This is an exciting opportunity to be part of a cross-functional team and contribute to the development of cutting-edge biotherapeutics in a fast-paced, rapidly growing biotech company with a bold vision.

Key Responsibilities Include But Are Not Limited To

• Collaborate closely with colleagues within the interdisciplinary research functions and Biologics Discovery and Drug Development team to drive the design, production and screen of therapeutic molecules, and the optimization of their biochemical/ biophysical properties.


• Play a key role in the development of innovative biologics drug candidates by participating in target feasibility assessment, leading efforts in building PoC molecules, and carrying out lead identification and optimization tasks using biochemical and cell-based assays.


• Independently execute high throughput multispecific antibody construct assembly, protein purification using various chromatography methods, biochemical potency and biophysical stability screening.


• Be responsible for experimental planning, execution, data analysis/interpretation, and communication with cross-functional teams for successful completion of projects.


• Ensure effective, high-quality, and timely documentation in electronic laboratory notebooks.

Qualifications

• Advanced degree required: MS or Ph.D in protein science, biochemistry, structure biology or other related disciplines


• Lab experience required: MS with 10+ years or PhD with 3+ years of relevant professional experience, industrial experience in antibody and biologics drug discovery and development field preferred


• Skilled in common molecular biology techniques, mammalian cell culture and recombinant protein expression using both transient and stable expression platforms


• Direct experience with various protein purification techniques including affinity, IEX, SEC and mixed mode chromatography using AKTA systems is required


• Proficient in routine biologics characterization and analytics technologies including BLI/SPR, ELISA, HPLC and UPLC; familiar with common cell-based assay platforms including plate readers and FACS


• Excellent written and oral communication, organization, and data analysis skills.Outstanding troubleshooting and problem-solving skills


• Highly adaptable to a fast-paced work environment and capable of working both independently and collaboratively within project teams