Scientist II, Protein Science (12-Month Position)

ModeX Therapeutics, Inc.; Weston (MA); On-site; USD 166,000 - 177,000; Full time

Job summary

ModeX Therapeutics, an OPKO Health company based in Weston, MA, seeks a highly skilled biochemist to join the Protein Science group. You will design, produce and characterize novel multispecific antibodies as part of a cross-functional team advancing cutting-edge biotherapeutics in a fast-paced biotech environment.

The role requires an advanced degree in protein science/biochemistry and extensive experience in antibody/biologics discovery, purification, and analytics.

Qualifications

• Advanced degree required: MS or PhD in protein science, biochemistry, structure biology or related fields.
• Lab experience: MS with 10+ years or PhD with 3+ years in antibody/biologics discovery and development.
• Proficient in mammalian cell culture and recombinant protein expression (transient and stable).
• Experience with protein purification techniques including affinity, IEX, SEC and mixed mode chromatography (AKTA).
• Familiar with BLI/SPR, ELISA, HPLC/UPLC and cell-based assay platforms.

Responsibilities

• Collaborate with Biologics Discovery and Drug Development to design, produce and screen multispecific antibodies.
• Lead feasibility assessments, build PoC molecules, and perform lead identification and optimization using biochemical and cell-based assays.
• Execute high-throughput multispecific antibody construct assembly and purification using chromatography methods.
• Plan experiments, analyze data, and communicate results to cross-functional teams.
• Maintain accurate, timely documentation in electronic lab notebooks.

Skills

Biochemistry

Protein purification

Molecular biology

Cell culture

Data analysis

Education

Advanced degree in protein science/biochemistry

Tools

AKTA chromatography

BLI/SPR

ELISA

HPLC/UPLC

FACS

Job description

#769

WESTON, Massachusetts, United States

Hiring In

WESTON , Massachusetts , United States

Position Type

Full-time (30+ Hours)

Work Schedule

Monday - Friday (9:00am - 5:30pm)

Company Overview

ModeX Therapeutics, an OPKO Health company, is the leading clinical-stage biopharmaceutical company developing unique and proprietary-multispecific therapeutics. Its MSTAR platform unites the power of multiple biologics in a single molecule to create multispecific antibodies that bind four or more targets with unprecedented versatility and potency for complex diseases. Its promising first-in-class immunology pipeline includes candidates against immune diseases, including cancer (both solid and hematologic tumors), immune impairment, as well as several of the world’s most pressing viral threats. Its founding team includes globally recognized medical innovators with proven track records of delivering breakthroughs for patients. ModeX is based in Weston, Massachusetts. For more information, please visit www.modextx.com .

Job Description

Location: Weston, MA

Reports To: Head of Protein Science

Company Overview:

ModeX Therapeutics, an OPKO Health company, is the leading clinical-stage biopharmaceutical company developing unique and proprietary multispecific therapeutics. Its MSTAR platform unites the power of multiple biologics in a single molecule to create multispecific antibodies that bind four or more targets with unprecedented versatility and potency for complex diseases. Its promising first-in-class immunology pipeline includes candidates against immune diseases, including cancer (both solid and hematologic tumors), immune impairment, as well as several of the world’s most pressing viral threats. Its founding team includes globally recognized medical innovators with proven track records of delivering breakthroughs for patients. ModeX is based in Weston, Massachusetts. For more information, please visit www.modextx.com .

Job Summary:

We are seeking a highly skilled and motivated biochemist to join our Protein Science group. The individual will be part of a multidisciplinary team to design, produce and characterize novel multispecific antibodies. This is an exciting opportunity to be part of a cross-functional team and contribute to the development of cutting-edge biotherapeutics in a fast-paced, rapidly growing biotech company with a bold vision.

Key responsibilities include but are not limited to:

• C ollaborate closely with colleagues within the interdisciplinary research functions and Biologics Discovery and Drug Development team to drive the design, production and screen of therapeutic molecules, and the optimization of their biochemical/ biophysical properties.
• Play a key role in the development of innovative biologics drug candidates by participating in target feasibility assessment, leading efforts in building PoC molecules, and carrying out lead identification and optimization tasks using biochemical and cell-based assays.
• Independently execute high throughput multispecific antibody construct assembly, protein purification using various chromatography methods, biochemical potency and biophysical stability screening.
• Be responsible for experimental planning, execution, data analysis/interpretation, and communication with cross-functional teams for successful completion of projects.
• Ensure effective, high-quality, and timely documentation in electronic laboratory notebooks.

Qualifications:

• Advanced degree required: MS or Ph.D in protein science, biochemistry, structure biology or other related disciplines
• Lab experience required: MS with 10+ years or PhD with 3+ years of relevant professional experience, industrial experience in antibody and biologics drug discovery and development field preferred
• Skilled in common molecular biology techniques, mammalian cell culture and recombinant protein expression using both transient and stable expression platforms
• Direct experience with various protein purification techniques including affinity, IEX, SEC and mixed mode chromatography using AKTA systems is required
• Proficient in routine biologics characterization and analytics technologies including BLI/SPR, ELISA, HPLC and UPLC; familiar with common cell-based assay platforms including plate readers and FACS
• Excellent written and oral communication, organization, and data analysis skills.Outstanding troubleshooting and problem-solving skills
• Highly adaptable to a fast-paced work environment and capable of working both independently and collaboratively within project teams

Pay Range

The estimated pay range for this job. Disclosing pay information promotes competitive and equitable pay. The actual pay rate will depend on the person's qualifications and experience.

$166,400.00 - $176,800.00 / year

Pay Transparency

In order to support the Fair Compensation Strategy by the US Govt., HR Dept., clients are required to adhere to "Pay Transparency Law"; in the impacted states; that have mandated the employers to list the salary ranges in Job advertisements or postings for job opportunities and Job promotions.

ModeX Therapeutics is an Equal Opportunity Employer.