Principal Scientist II, Immunology

ModeX Therapeutics Inc.; Weston (MA); On-site; USD 207,000 - 222,000; Full time

Job summary

ModeX Therapeutics, based in Weston, Massachusetts, seeks a Principal Scientist II, Immunology to lead discovery and preclinical development of multispecific biologics for immuno-oncology and immunology/inflammation indications.

This role provides scientific and strategic leadership across the full discovery lifecycle, from concept through IND-enabling development, collaborating with cross-functional teams to translate innovative biology into candidate therapies.

Qualifications

• Master’s degree in Immunology or related field with extensive research experience.
• Strong track record in immunology and immuno-oncology biology.
• Experience leading multispecific antibody programs or complex biologics is preferred.

Responsibilities

• Provide scientific and strategic leadership for multispecific therapeutic programs.
• Identify and validate targets, mechanisms, and multispecific formats.
• Lead target validation, molecule characterization, and candidate selection.
• Design and oversee in vitro, ex vivo, and in vivo studies evaluating MOA, potency, and pharmacology.
• Generate integrated data packages supporting preclinical development and IND-enabling studies.
• Mentor scientists and collaborate with cross-functional teams.

Skills

Leadership

Cross-functional collaboration

Strategic thinking

Communication

Experimental design

Mentoring

Education

Master's Degree in Immunology

Ph.D. preferred

Job description

ModeX Therapeutics, an OPKO Health company, is the leading clinical-stage biopharmaceutical company developing unique and proprietary-multispecific therapeutics. Its MSTAR platform unites the power of multiple biologics in a single molecule to create multispecific antibodies that bind four or more targets with unprecedented versatility and potency for complex diseases. Its promising first-in-class immunology pipeline includes candidates against immune diseases, including cancer (both solid and hematologic tumors), immune impairment, as well as several of the world's most pressing viral threats. Its founding team includes globally recognized medical innovators with proven track records of delivering breakthroughs for patients. ModeX is based in Weston, Massachusetts. For more information, please visit www.modextx.com .

Job Description

ModeX Therapeutics is seeking a highly skilled and motivated Principal Scientist II, Immunology to play a leading scientific role in the discovery and preclinical development of novel multispecific biologics for immuno-oncology and immunology/inflammation indications. The successful candidate will play a central role across the full discovery lifecycle; from identifying therapeutic concepts and designing differentiated multispecific molecules through mechanistic characterization, candidate selection, and advancement into IND-enabling development. This individual will provide scientific and strategic leadership, work closely with cross-functional teams, and help translate innovative biology into IND-ready therapeutic candidates.

This is an exciting opportunity to contribute to the development of next-generation immune therapies in a fast-paced and collaborative biotechnology environment.

Key Responsibilities:

• Provide scientific and strategic leadership for multispecific therapeutic programs in immuno-oncology and immunology/inflammation, from early ideation through IND-enabling development.
• Identify and evaluate novel targets, target combinations, mechanisms, and multispecific formats aligned with the company's research and pipeline strategy.
• Develop differentiated therapeutic concepts and define clear biological hypotheses, candidate profiles, and experimental strategies.
• Lead target validation, molecule characterization, lead optimization, and candidate-selection activities.
• Design and oversee robust in vitro, ex vivo, and in vivo studies to evaluate mechanism of action, potency, selectivity, target engagement, pharmacology, and translational relevance.
• Establish and apply screening cascades and decision criteria to prioritize molecules and advance programs through key stage gates.
• Generate integrated data packages supporting preclinical development, IND-enabling studies, regulatory documentation, and external partnering activities.
• Identify scientific, technical, and translational risks and develop appropriate mitigation strategies.
• Collaborate closely with protein engineering, antibody discovery, translational sciences, CMC, clinical, regulatory, and business-development teams.
• Lead, mentor, and develop scientists and research associates while fostering a collaborative, inclusive, and high-performing team culture.
• Ensure scientific rigor, data quality, and clear documentation across experimental design, data interpretation, and program decision-making.
• Monitor emerging scientific and competitive developments and incorporate relevant insights into research strategy and portfolio planning.
• Present program strategies, results, recommendations, and risks to research teams, senior leadership, collaborators, and external partners.

Qualifications:

• Master’s Degree in Immunology, Immuno-Oncology, Cancer Biology, or a related discipline, with 13+ years of relevant research experience, including at least 7+ years in a biotech or pharmaceutical R&D environment. Ph.D. preferred.
• Deep expertise in immunology and immuno-oncology disease biology.
• Demonstrated track record of advancing biologic therapeutic programs from early discovery through preclinical development and IND-enabling activities.
• Experience developing multispecific antibodies, immune-cell engagers, antibody-based therapeutics, or other complex biologic modalities is strongly preferred.
• Strong understanding of target biology, mechanism-of-action studies, translational pharmacology, and preclinical candidate selection.
• Extensive experience designing and interpreting in vitro, ex vivo, and in vivo studies relevant to immune-modulating therapeutics.
• Expert-level proficiency in multicolor flow cytometry is required, including panel design and optimization, assay development, instrument setup, data analysis, troubleshooting, and interpretation of complex immune-cell phenotypes.
• Demonstrated ability and willingness to work hands-on in the laboratory when needed, including supporting critical experiments, troubleshooting assays, and helping the team meet key program milestones.
• Proven ability to develop integrated research strategies, establish program priorities, and make data-driven decisions under uncertainty.
• Demonstrated experience leading cross-functional discovery teams and influencing program strategy within a matrixed organization.
• Strong leadership and mentoring skills, with experience developing high-performing scientific teams.
• Excellent written and verbal communication skills, including the ability to clearly communicate complex scientific concepts, recommendations, and risks.
• Strong organizational skills and the ability to manage multiple programs and priorities in a dynamic research environment.
• Demonstrated scientific creativity, strategic thinking, adaptability, and commitment to innovation and scientific rigor.

ModeX Therapeutics is an Equal Opportunity Employer

ModeX Therapeutics is an Equal Opportunity Employer.

Click here for the full definition of our EEO statement.

ModeX Therapeutics is an Equal Opportunity Employer.

Pay Range

$207,000.00 - $222,000.00 / year

Pay Transparency

In order to support the Fair Compensation Strategy by the US Govt., HR Dept., clients are required to adhere to "Pay Transparency Law"; in the impacted states; that have mandated the employers to list the salary ranges in Job advertisements or postings for job opportunities and Job promotions.