Protein Science Scientist II: Multispecific Biologics

ModeX Therapeutics, Inc.; Weston (MA); On-site; USD 166,000 - 177,000; Full time

Job summary

ModeX Therapeutics, an OPKO Health company based in Weston, MA, seeks a highly skilled biochemist to join the Protein Science group. You will design, produce and characterize novel multispecific antibodies as part of a cross-functional team advancing cutting-edge biotherapeutics in a fast-paced biotech environment.

The role requires an advanced degree in protein science/biochemistry and extensive experience in antibody/biologics discovery, purification, and analytics.

Qualifications

• Advanced degree required: MS or PhD in protein science, biochemistry, structure biology or related fields.
• Lab experience: MS with 10+ years or PhD with 3+ years in antibody/biologics discovery and development.
• Proficient in mammalian cell culture and recombinant protein expression (transient and stable).
• Experience with protein purification techniques including affinity, IEX, SEC and mixed mode chromatography (AKTA).
• Familiar with BLI/SPR, ELISA, HPLC/UPLC and cell-based assay platforms.

Responsibilities

• Collaborate with Biologics Discovery and Drug Development to design, produce and screen multispecific antibodies.
• Lead feasibility assessments, build PoC molecules, and perform lead identification and optimization using biochemical and cell-based assays.
• Execute high-throughput multispecific antibody construct assembly and purification using chromatography methods.
• Plan experiments, analyze data, and communicate results to cross-functional teams.
• Maintain accurate, timely documentation in electronic lab notebooks.

Skills

Biochemistry

Protein purification

Molecular biology

Cell culture

Data analysis

Education

Advanced degree in protein science/biochemistry

Tools

AKTA chromatography

BLI/SPR

ELISA

HPLC/UPLC

FACS

Job description

ModeX Therapeutics, an OPKO Health company based in Weston, MA, seeks a highly skilled biochemist to join the Protein Science group. You will design, produce and characterize novel multispecific antibodies as part of a cross-functional team advancing cutting-edge biotherapeutics in a fast-paced biotech environment.

The role requires an advanced degree in protein science/biochemistry and extensive experience in antibody/biologics discovery, purification, and analytics.